Gilman Barber Ashley R, Rhone Stephanie A, Fluker Margo R
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver BC.
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver BC; Early Pregnancy Assessment Clinic, BC Women's Hospital and Health Centre, Vancouver BC.
J Obstet Gynaecol Can. 2014 Nov;36(11):997-1001. doi: 10.1016/S1701-2163(15)30413-8.
To investigate the noted cluster of cases of Asherman's syndrome in an 18-month period at an Early Pregnancy Assessment Centre at a tertiary care institution.
A practice audit was performed involving (a) a detailed chart review of the six index cases; and (b) compilation of treatment choices for all new patient referrals in the same 18-month time frame from July 2011 to December 2012. Diagnosis of Asherman's syndrome was made with a combination of clinical menstrual symptoms and hysteroscopic diagnosis of intrauterine adhesions.
Of 1580 new patient referrals, 884 chose one of four forms of active management for early pregnancy failure. Six women (6/844, 0.7%) were subsequently found to have Asherman's syndrome. All six women (100%) underwent sharp curettage, and three (50%) had repeat curettage performed. No cases of Asherman's were reported following manual vacuum aspiration (0/191) or medical management with misoprostol (0/210).
Asherman's syndrome remains a risk for those undergoing dilatation and curettage for management of spontaneous abortion and should be an important component of the informed consent for this procedure. Both sharp and repeated curettage remain important risk factors and should be employed judiciously. The evaluation of the common risk factors associated with these cases could target changes in practice.
调查在一家三级医疗机构的早期妊娠评估中心18个月期间记录的阿谢曼综合征病例群。
进行了一项实践审核,包括:(a) 对6例索引病例进行详细的病历审查;(b) 汇总2011年7月至2012年12月同一18个月时间范围内所有新患者转诊的治疗选择。阿谢曼综合征的诊断结合临床月经症状和宫腔镜检查对宫腔粘连的诊断。
在1580例新患者转诊中,884例选择了四种积极处理早期妊娠失败的方式之一。随后发现6名女性(6/844,0.7%)患有阿谢曼综合征。所有6名女性(100%)均接受了刮宫术,其中3名(50%)进行了再次刮宫。人工负压吸引(0/191)或米索前列醇药物治疗(0/210)后未报告阿谢曼综合征病例。
对于因自然流产接受刮宫术的患者,阿谢曼综合征仍然是一种风险,应作为该手术知情同意的重要组成部分。刮宫术和重复刮宫术仍然是重要的风险因素,应谨慎使用。对与这些病例相关的常见风险因素进行评估可针对实践中的变化。