磷脂和萜烯调节 Caco-2 对巴西莓花色苷的转运。
Phospholipids and terpenes modulate Caco-2 transport of açaí anthocyanins.
机构信息
Department of Nutrition and Food Science, Texas A&M University, College Station, TX 77843-2254, United States; Department of Food Science and Technology, Pan-American School of Agriculture, Zamorano University, PO Box 93, Tegucigalpa, Honduras.
Department of Nutrition and Food Science, Texas A&M University, College Station, TX 77843-2254, United States; Department of Vet. Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, United States.
出版信息
Food Chem. 2015 May 15;175:267-72. doi: 10.1016/j.foodchem.2014.11.119. Epub 2014 Nov 28.
Anthocyanins (ANC) are common polyphenolics in plants, but are poorly absorbed into the bloodstream upon consumption. Phospholipids (PL) and terpenes (TP) may serve as enhancing agents in absorption. This study evaluated their role in transepithelial transport within a Caco-2 cell monolayer-model system and impact on ANC stability. Açaí fruit ANC were isolated and found to transport, at a low rate (1.22%), in the absence of soy lecithin phospholipids and Valencia orange terpenes, yet their addition significantly increased the transport of both cyanidin-3-glucoside and cyanidin-3-rutinoside. The best transport results (5.21%) were observed when combinations of PL (5000 mg/l) and TP (50mg/l) were used. The presence of PL and TP had no influence on ANC degradation over a 40 day storage period. Results demonstrated the potential of PL and TP to increase intestinal transport of ANC, and present advancement towards the formulation of functional foods that support improved ANC absorption.
花色苷（ANC）是植物中常见的多酚类物质，但在食用后很难被吸收到血液中。磷脂（PL）和萜烯（TP）可作为吸收的增强剂。本研究评估了它们在 Caco-2 细胞单层模型系统中的跨上皮转运中的作用及其对 ANC 稳定性的影响。从巴西莓果实中分离出 ANC，发现其在没有大豆卵磷脂磷脂和瓦伦西亚橙萜烯的情况下转运速度较慢（1.22%），但添加这些物质后，花色苷-3-葡萄糖苷和花色苷-3-鼠李糖苷的转运速度显著增加。当 PL（5000mg/L）和 TP（50mg/L）组合使用时，观察到最佳的转运效果（5.21%）。在 40 天的储存期内，PL 和 TP 的存在对 ANC 的降解没有影响。结果表明，PL 和 TP 有可能增加 ANC 在肠道中的转运，这是朝着开发支持 ANC 吸收改善的功能性食品的方向迈出的一步。
Zotero 插件