在为期1年的时间里，用丙酸氟替卡松治疗的慢性阻塞性肺疾病马匹的血清皮质醇浓度。

Serum cortisol concentration in horses with heaves treated with fluticasone proprionate over a 1 year period.

作者信息

Munoz Trohadio, Leclere Mathilde, Jean Daniel, Lavoie Jean-Pierre

机构信息

Clinical Sciences Department, Faculty of Veterinary Medicine, Université de Montréal, 3200 Sicotte, St-Hyacinthe, QC, Canada J2S 7C6.

出版信息

Res Vet Sci. 2015 Feb;98:112-4. doi: 10.1016/j.rvsc.2014.12.013. Epub 2014 Dec 23.

DOI:10.1016/j.rvsc.2014.12.013

PMID:25577545

Abstract

The purpose of this study is to measure the effect of long-term administration of inhaled fluticasone proprionate on cortisol concentrations in heaves-affected horses. Eleven horses with heaves were treated with fluticasone at least once daily at dosages required to improve lung function or with antigen avoidance alone for 1 year. Morning serum cortisol was measured before and after 10, 30, 110, 190, 230, 280, and 320 days of treatment. Cortisol was also measured in the afternoon of day 330. Cortisol was significantly lower in the Fluticasone group on days 30, 110, and 190 when compared with the Antigen avoidance group. Cortisol measured on day 330 was also significantly lower in the Fluticasone group. Results indicate that inhaled fluticasone, when administered at therapeutic dosages, can significantly suppress serum cortisol concentrations for 8-24 h. The clinical significance of this finding remains to be ascertained, as no clinical signs were associated with this cortisol suppression.

摘要

本研究的目的是测定长期吸入丙酸氟替卡松对患慢性阻塞性肺病马的皮质醇浓度的影响。11匹患慢性阻塞性肺病的马，每天至少接受一次丙酸氟替卡松治疗，剂量以改善肺功能所需为准，或仅采取避免接触抗原的措施，为期1年。在治疗的第10、30、110、190、230、280和320天前后测量早晨血清皮质醇。在第330天下午也测量了皮质醇。与避免接触抗原组相比，丙酸氟替卡松组在第30、110和190天的皮质醇水平显著较低。在第330天测量时，丙酸氟替卡松组的皮质醇水平也显著较低。结果表明，以治疗剂量吸入丙酸氟替卡松可显著抑制血清皮质醇浓度8 - 24小时。这一发现的临床意义尚待确定，因为没有临床症状与这种皮质醇抑制相关。