Sager Sait, Asa Sertaç, Yilmaz Mehmet, Uslu Lebriz, Vatankulu Betul, Halaç Metin, Sönmezoglu Kerim, Kanmaz Bedii
Department of Nuclear Medicine, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.
J Cancer Res Ther. 2014 Oct-Dec;10(4):922-6. doi: 10.4103/0973-1482.137968.
It has been previously reported that metabolic tumor volume on positron emission tomography-computed tomography predicts disease recurrence and death in head-and-neck cancer. In this study, we assessed the prognostic value of metabolic tumor volume measured using F18-Fluorodeoxyglucose PET/CT in patients with head and neck squamous cell carcinoma.
We analyzed the imaging findings of 74 patients (age 57±16) retrospectively, with head and neck cancer who underwent PET/CT scan for staging and after treatment. Forty-tree patients had nasopharynx, 15 patients had hypopharynx, 9 patients had larynx, and 7 patients had oropharynx cancer. The MTVs of primary sites with or without lymph nodes were measured, and outcomes were assessed using the treatment response evaluation by the Response Evaluation Criteria in Solid Tumors and recurrence events during follow-up.
A total of 48 patients had complete response or no recurrence was detected as of in the last follow-up. Of the first PET/CT scan, the median primary tumor SUVmax was 18.8 and the median nodal SUVmax was 13.4. The median primary tumor MTV% 50s ranged from 11.12 cm3 to 16.28 cm3, and the MTV after the therapy ranged from 1.18 cm3 to 3.51 cm3.
Metabolic tumor volume (MTV) represents tumor burden, which shows F18-Fluorodeoxyglucose uptake and has a potential value in predicting short-term outcome and disease-free survival in patients with head and neck cancer.
先前已有报道称，正电子发射断层扫描-计算机断层扫描（PET-CT）上的代谢肿瘤体积可预测头颈癌的疾病复发和死亡情况。在本研究中，我们评估了使用F18-氟脱氧葡萄糖PET/CT测量的代谢肿瘤体积在头颈部鳞状细胞癌患者中的预后价值。
我们回顾性分析了74例（年龄57±16岁）接受PET/CT扫描以进行分期及治疗后的头颈癌患者的影像学检查结果。43例患者患有鼻咽癌，15例患有下咽癌，9例患有喉癌，7例患有口咽癌。测量了有或无淋巴结的原发部位的代谢肿瘤体积（MTV）,并使用实体瘤疗效评价标准评估治疗反应及随访期间的复发事件来评估预后。
截至最后一次随访，共有48例患者获得完全缓解或未检测到复发。在首次PET/CT扫描中，原发肿瘤SUVmax的中位数为18.8，淋巴结SUVmax的中位数为13.4。原发肿瘤MTV%50s的中位数范围为11.12 cm³至16.28 cm³，治疗后的MTV范围为1.18 cm³至3.51 cm³。
代谢肿瘤体积（MTV）代表肿瘤负荷，显示F18-氟脱氧葡萄糖摄取情况，对头颈癌患者的短期预后和无病生存期具有潜在的预测价值。
