与男性发生性关系且患有肛门鳞状上皮内病变的男性的口腔人乳头瘤病毒感染
Oral human papillomavirus infection in men who have sex with men with anal squamous intraepithelial lesions.
作者信息
Prendes Brandon L, Wang Steven J, Groppo Eli R, Eisele David W, Palefsky Joel M
机构信息
Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, California.
Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.
出版信息
Head Neck. 2016 Apr;38 Suppl 1:E399-405. doi: 10.1002/hed.24006. Epub 2015 Jun 29.
BACKGROUND
Little is known about the association between oral and anogenital human papillomavirus (HPV) infections.
METHODS
Oral and anal samples from 66 men who have sex with men with a history of HPV-related anogenital squamous intraepithelial lesions were analyzed using polymerase chain reaction (PCR), and typed for 38 HPV types.
RESULTS
Prevalence of oral HPV infection was 30%, versus 82% for anal infection. Prevalence of oral and anal high-risk HPV infection was 11% and 64%, respectively. Concurrent oral-anal any-type HPV infection was found in 26% of participants, whereas concordant type-specific HPV prevalence was 5%. In multivariate analysis, number of partners from whom the participant received oral-penile sex and number of partners on whom the participant performed oral-penile sex were associated with oral HPV infection.
CONCLUSION
Oral HPV prevalence in this cohort is high, however, concordant type-specific oral-anal HPV infection was rare. Increased risk of oral HPV infection was associated with oral-penile sex. © 2015 Wiley Periodicals, Inc. Head Neck 38: E399-E405, 2016.
背景
关于口腔与肛门生殖器人乳头瘤病毒（HPV）感染之间的关联，人们了解甚少。
方法
对66名有HPV相关肛门生殖器鳞状上皮内病变病史的男男性行为者的口腔和肛门样本进行聚合酶链反应（PCR）分析，并对38种HPV类型进行分型。
结果
口腔HPV感染率为30%，而肛门感染率为82%。口腔和肛门高危HPV感染率分别为11%和64%。26%的参与者存在口腔 - 肛门同时感染任何类型HPV的情况，而相同型别HPV的一致感染率为5%。在多变量分析中，参与者接受口交的性伴侣数量以及参与者对其进行口交的性伴侣数量与口腔HPV感染相关。
结论
该队列中的口腔HPV感染率较高，然而，相同型别的口腔 - 肛门HPV一致感染情况罕见。口腔HPV感染风险增加与口交行为有关。©2015威利期刊公司。头颈外科38: E399 - E405，2016年。
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