用BRAF抑制剂达拉非尼联合治疗毛细胞白血病和黑色素瘤。
Cotreatment of hairy cell leukemia and melanoma with the BRAF inhibitor dabrafenib.
作者信息
Blachly James S, Lozanski Gerard, Lucas David M, Grever Michael R, Kendra Kari, Andritsos Leslie A
机构信息
From the Division of Hematology, Department of Internal Medicine, Department of Pathology, and Division of Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
出版信息
J Natl Compr Canc Netw. 2015 Jan;13(1):9-13; quiz 13. doi: 10.6004/jnccn.2015.0004.
Abstract
The activating BRAF mutation p.V600E has been identified in many cancers, including colon and lung adenocarcinomas, papillary thyroid cancer, malignant melanoma, and hairy cell leukemia (HCL). Malignant melanoma and HCL are of particular interest because of both the high proportion of cases harboring the mutation and the dramatic responses to BRAF inhibitor therapy reported in the literature. This report presents a patient with HCL and malignant melanoma with the BRAF p.V600E mutation, and discusses the successful treatment of both cancers with the BRAF inhibitor dabrafenib.
摘要
激活型BRAF突变p.V600E已在多种癌症中被发现，包括结肠腺癌和肺腺癌、甲状腺乳头状癌、恶性黑色素瘤和毛细胞白血病（HCL）。恶性黑色素瘤和HCL尤其值得关注，因为携带该突变的病例比例较高，且文献报道其对BRAF抑制剂治疗有显著反应。本报告介绍了一名患有HCL和恶性黑色素瘤且伴有BRAF p.V600E突变的患者，并讨论了使用BRAF抑制剂达拉非尼成功治疗这两种癌症的情况。
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