经验性幻觉在颞叶癫痫中的偏侧化价值。
Lateralising value of experiential hallucinations in temporal lobe epilepsy.
机构信息
Laboratory of Cognitive Neuroscience, Brain-Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Switzerland Department of Neurology, University Hospital Geneva, Geneva, Switzerland.
Laboratory of Cognitive Neuroscience, Brain-Mind Institute, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Switzerland.
出版信息
J Neurol Neurosurg Psychiatry. 2015 Nov;86(11):1273-6. doi: 10.1136/jnnp-2014-309452. Epub 2015 Jan 13.
OBJECTIVES
Ever since John Hughlings Jackson first described the so-called 'dreamy state' during temporal lobe epilepsy, that is, the sense of an abnormal familiarity (déjà vu) or vivid memory-like hallucinations from the past (experiential hallucinations), these phenomena have been studied and repeatedly linked to mesial temporal lobe structures. However, little is known about the lateralising value of either déjà vu or experiential hallucinations.
METHODS
We analysed a sample of 28 patients with intractable focal epilepsy suffering from either déjà vu or experiential hallucinations. All the patients underwent thorough presurgical examination, including MRI, positron emission tomography, single-photon emission CT, EEG and neuropsychological examination.
RESULTS
While déjà vu was due to right or left mesial temporal lobe epilepsy, experiential hallucinations were strongly lateralised to the left mesial temporal lobe. Moreover, there was a significant effect for interictal language deficits being more frequent in patients suffering from experiential hallucinations.
CONCLUSIONS
These results suggest a lateralising value for experiential hallucinations to the left temporal lobe.
目的
自从约翰·休林斯·杰克逊（John Hughlings Jackson）首次描述颞叶癫痫（temporal lobe epilepsy）中的所谓“梦幻状态”，即异常熟悉感（déjà vu）或生动的似曾经历过的幻觉（experiential hallucinations）以来，这些现象一直受到研究，并反复与内侧颞叶结构相关联。然而，对于déjà vu 或 experiential hallucinations 的定位价值却知之甚少。
方法
我们分析了 28 例患有难治性局灶性癫痫的患者，这些患者均有déjà vu 或 experiential hallucinations 现象。所有患者均接受了彻底的术前检查，包括 MRI、正电子发射断层扫描、单光子发射 CT、脑电图和神经心理学检查。
结果
尽管déjà vu 是由右侧或左侧内侧颞叶癫痫引起的，但 experiential hallucinations 强烈偏向于左侧内侧颞叶。此外，发作间期语言缺陷更常见于患有 experiential hallucinations 的患者，这具有显著的影响。
结论
这些结果表明 experiential hallucinations 对左侧颞叶具有定位价值。
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