Kunkel M, Rusche T, Oberender H, Richter I, Radke M, Czieschnek R
Institut für Medizinische Mikrobiologie. Bereichs Medizin der Wilhelm-Pieck-Universität Rostock.
Zentralbl Gynakol. 1989;111(23):1567-71.
Most neonatal Herpes-simplex-virus infections are the result of virus acquisition during passage through the birth canal. Transplacental transmission of HSV is seldom. The infection is mostly localized at the skin, eyes and central nervous system. The disseminated HSV-infection represents as the most severe clinical picture. It is reported about meningoencephalitis caused by HSV in 3 infants in the first weeks of life. The therapeutic success of antiviral chemotherapeutics depends very much on their application at an early stage of the disease, which can be recognized by cerebral sonography and detection of IgM-antibodies against HSV.
大多数新生儿单纯疱疹病毒感染是在通过产道时获得病毒所致。单纯疱疹病毒经胎盘传播很少见。感染多局限于皮肤、眼睛和中枢神经系统。播散性单纯疱疹病毒感染表现为最严重的临床症状。据报道，在出生后第一周内，有3名婴儿发生了由单纯疱疹病毒引起的脑膜脑炎。抗病毒化疗药物的治疗成功很大程度上取决于在疾病早期的应用，这可通过脑部超声检查和检测抗单纯疱疹病毒的IgM抗体来识别。
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