前列腺素在肾集合管和髓袢升支粗段的生物合成及作用

The biosynthesis and actions of prostaglandins in the renal collecting tubule and thick ascending limb.

作者信息

Smith W L, Sonnenburg W K, Allen M L, Watanabe T, Zhu J, el-Harith E A

机构信息

Department of Biochemistry, Michigan State University, East Lansing 48824.

出版信息

Adv Exp Med Biol. 1989;259:131-47. doi: 10.1007/978-1-4684-5700-1_6.

DOI:10.1007/978-1-4684-5700-1_6

PMID:2560343

Abstract

PGE2 formed by renal collecting tubules is an important factor in regulating NaCl and water reabsorption in the collecting tubule and medullary thick ascending limb. PGE2 appears to act, depending on its ambient concentration, via several different receptors present in these renal epithelia to modulate cAMP turnover in both positive and negative directions. These putative PGE receptors form a family of receptors, all coupled to G proteins, and this family of PGE receptors is homologous to the adrenergic receptor family.

摘要

肾集合管形成的前列腺素E2是调节集合管和髓袢升支粗段氯化钠和水重吸收的重要因素。根据其周围浓度，前列腺素E2似乎通过这些肾上皮细胞中存在的几种不同受体发挥作用，以正向和负向调节环磷酸腺苷（cAMP）的周转。这些假定的前列腺素受体形成了一个受体家族，均与G蛋白偶联，并且这个前列腺素受体家族与肾上腺素能受体家族同源。