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黄金大米:一种转基因生物的科学、监管及公众信息流程

Golden rice: scientific, regulatory and public information processes of a genetically modified organism.

作者信息

Moghissi A Alan, Pei Shiqian, Liu Yinzuo

机构信息

a Microbiology and Immunology, Georgetown School of Medicine , Washington , DC , USA .

b International Center for Regulatory Science , George Mason University , Arlington , VA , USA .

出版信息

Crit Rev Biotechnol. 2016;36(3):535-41. doi: 10.3109/07388551.2014.993586. Epub 2015 Jan 21.

Abstract

Historically, agricultural development evolved in three phases. During the first phase the plants were selected on the basis of the availability of a plant with desirable properties at a specific location. The second phase provided the agricultural community with crossbreeding plants to achieve improvement in agricultural production. The evolution of biological knowledge has provided the ability to genetically engineer (GE) crops, one of the key processes within genetically modified organisms (GMO). This article uses golden rice, a species of transgenic Asian rice which contains a precursor of vitamin A in the edible part of the plant as an example of GE/GMO emphasizing Chinese experience in agricultural evolution. It includes a brief review of agricultural evolution to be followed by a description of golden rice development. Golden rice was created as a humanitarian project and has received positive comments by the scientific community and negative voices from certain environmental groups. In this article, we use the Best Available Science (BAS) Concept and Metrics for Evaluation of Scientific Claims (MESC) derived from it to evaluate claims and counter claims on scientific aspects of golden rice. This article concludes that opposition to golden rice is based on belief rather than any of its scientifically derived nutritional, safety or environmental properties.

摘要

从历史角度来看,农业发展经历了三个阶段。在第一阶段,植物的选择是基于特定地点具有理想特性的植物的可获得性。第二阶段为农业社区提供了杂交植物,以实现农业生产的改善。生物学知识的发展使得对作物进行基因工程改造成为可能,这是转基因生物(GMO)中的关键过程之一。本文以黄金大米为例,它是一种转基因亚洲水稻,在植物的可食用部分含有维生素A的前体,以此强调中国在农业发展方面的经验。文章首先简要回顾农业发展历程,随后描述黄金大米的研发情况。黄金大米是作为一个人道主义项目培育出来的,受到了科学界的积极评价,但也遭到了某些环保组织的反对。在本文中,我们使用“最佳现有科学”(BAS)概念以及由此衍生的“科学主张评估指标”(MESC)来评估关于黄金大米科学方面的主张和反驳主张。本文得出结论,对黄金大米的反对基于信念,而非其任何科学得出的营养、安全或环境特性。

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