Younas Haroon, Sabir Omer, Baig Ilyas, Tarif Nauman
Department of Nephrology, Fatima Memorial Hospital, University of Health Sciences, Lahore.
Department of Medicine, Fatima Memorial Hospital, University of Health Sciences, Lahore.
J Coll Physicians Surg Pak. 2015 Jan;25(1):73-5.
Hyponatremia secondary to the Syndrome of Inappropriate Anti-Diuretic Hormone (SIADH) secretion is commonly observed in patients with various neurological disorders. Cerebral Salt Wasting (CSW) resulting in hyponatremia is also an infrequent occurrence in some patients with neurological disorders. Confusion in differentiating CSW from SIADH may arise since both results in similar electrolyte disturbances. Herein, we report three cases of CSW with intracranial afflictions. CSW was diagnosed on the basis of fractional excretion of urinary sodium and uric acid along with extremely low serum uric acid. Improvements in serum sodium levels after saline hydration and fludrocortisone administration further supported the diagnosis.
抗利尿激素分泌异常综合征（SIADH）继发的低钠血症常见于各种神经系统疾病患者。导致低钠血症的脑性盐耗综合征（CSW）在一些神经系统疾病患者中也不常见。由于CSW和SIADH都会导致相似的电解质紊乱，因此在区分两者时可能会出现混淆。在此，我们报告3例伴有颅内病变的CSW病例。CSW是根据尿钠和尿酸的分数排泄以及极低的血清尿酸水平诊断出来的。生理盐水水化和给予氟氢可的松后血清钠水平的改善进一步支持了诊断。
