Parimi Vamsi, Goyal Rajen, Poropatich Kate, Yang Ximing J
Robert H Lurie Comprehensive Cancer Center Chicago, IL.
Department of Pathology, Northwestern University Chicago, IL.
Am J Clin Exp Urol. 2014 Dec 9;2(4):273-85. eCollection 2014.
Neuroendocrine cells are one of the epithelial populations in the prostate. Neuroendocrine differentiation (NED) has been observed in prostate cancer. In addition to small cell neuroendocrine carcinomas and carcinoid tumors of the prostate, prostatic adenocarcinomas may have NED. The incidence and clinical relevance of NED in prostatic adenocarcinoma is not clearly understood because of conflicting results in the reported studies, and evaluation of NED is not routinely performed in clinical practice. This review is an overall synthesis with an aim to develop a more comprehensive understanding and practical approach towards the current knowledge of neuroendocrine differentiation. In this review we are stratifying these lesions into separate subtypes based on histologic parameters such as tumor morphology, neuroendocrine cell density and distribution and clinical parameters. We also want to identify current controversies and confusing issues not totally resolved in this topic for further investigations. Eventually a clearer understanding of this phenomenon and appropriate handling NED in prostate cancer will benefit clinical practice.
神经内分泌细胞是前列腺中的上皮细胞群体之一。在前列腺癌中已观察到神经内分泌分化（NED）。除了前列腺小细胞神经内分泌癌和类癌肿瘤外，前列腺腺癌也可能有神经内分泌分化。由于报道的研究结果相互矛盾，前列腺腺癌中神经内分泌分化的发生率和临床相关性尚不清楚，并且在临床实践中并非常规进行神经内分泌分化的评估。本综述是一个全面的综合，旨在对神经内分泌分化的现有知识形成更全面的理解和实用方法。在本综述中，我们根据组织学参数（如肿瘤形态、神经内分泌细胞密度和分布）和临床参数将这些病变分为不同的亚型。我们还希望识别该主题中尚未完全解决的当前争议和令人困惑的问题，以供进一步研究。最终，对这一现象的更清晰理解以及对前列腺癌中神经内分泌分化的适当处理将有益于临床实践。
