Stefanowicz Magdalena, Strączkowski Marek, Karczewska-Kupczewska Monika
Zakład Chorób Metabolicznych, Uniwersytet Medyczny w Białymstoku.
Zakład Chorób Metabolicznych, Uniwersytet Medyczny w Białymstoku; Zakład Profilaktyki Chorób Metabolicznych, Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie.
Postepy Hig Med Dosw (Online). 2015 Jan 16;69:63-8. doi: 10.5604/17322693.1136379.
Skeletal muscle insulin resistance manifests as a decreased ability of insulin to stimulate glucose uptake in consequence of an impairment in its intracellular signaling. Sirtuin 1 (SIRT1), which belongs to the family of sirtuins (Sir2; silent information regulator 2 protein) participates in the regulation of skeletal muscle glucose and lipid metabolism. Experimental studies indicate that SIRT1 may play a role in the pathogenesis of skeletal muscle insulin resistance. SIRT1 directly influences insulin signal transduction pathway. It increases insulin-dependent IRS2 phosphorylation and Akt activation. Moreover, SIRT1 interacts with PGC1α and AMPK to stimulate muscle glucose uptake and fatty acid oxidation and thus it can prevent insulin resistance. SIRT1 activators might be useful in the treatment of insulin resistance-related diseases.
骨骼肌胰岛素抵抗表现为胰岛素刺激葡萄糖摄取的能力下降，这是由于其细胞内信号传导受损所致。属于沉默信息调节因子2蛋白（Sir2）家族的沉默信息调节因子1（SIRT1）参与骨骼肌葡萄糖和脂质代谢的调节。实验研究表明，SIRT1可能在骨骼肌胰岛素抵抗的发病机制中起作用。SIRT1直接影响胰岛素信号转导通路。它增加胰岛素依赖性IRS2磷酸化和Akt激活。此外，SIRT1与PGC1α和AMPK相互作用，以刺激肌肉葡萄糖摄取和脂肪酸氧化，从而预防胰岛素抵抗。SIRT1激活剂可能对治疗胰岛素抵抗相关疾病有用。
