与骨关节炎治疗相关的因素：墨西哥新莱昂州COPCORD研究分析
Factors associated with treatment of osteoarthritis: Analysis of a COPCORD study in Nuevo León, México.
作者信息
Hernández-Cáceres Alexia Estefanía, Rodriguez-Amado Jacqueline, Peláez-Ballestas Ingris, Vega-Morales David, Garza-Elizondo Mario Alberto
机构信息
Department Internal Medicine, Rheumatology Service, Hospital Universitario "Dr. José Eleuterio González", Monterrey, Nuevo León, Mexico.
Department of Rheumatology, Hospital General de México "Dr. Eduardo Liceaga", Ciudad de México, Distrito Federal, Mexico.
出版信息
Reumatol Clin. 2015 Jul-Aug;11(4):204-9. doi: 10.1016/j.reuma.2014.08.001. Epub 2015 Jan 24.
INTRODUCTION
Osteoarthritis (OA) is the most prevalent rheumatic disease in Mexico. Treatment involves pharmacological and non-pharmacological strategies.
OBJECTIVE
To describe the factors associated with treatment of osteoarthritis in the urban and rural population of Nuevo León.
METHODS
Analysis of a cross-sectional study of patients with OA from a COPCORD study database. Univariate and multivariate analyses of the variables associated with treatment of OA.
RESULTS
We included 696 patients with OA with an average age of 58 years (SD 14.1), 484 (69.5%) women. Pain with a visual analog scale (VAS) ≥4 was present in 507 (72.8%) patients. Functional disability was present in 133 (19%) patients and a mean HAQ of 0.37 (IQR 0.75) was found. The most frequent place of OA was knee in 356 (51.1%) patients; 259 (37%) patients already knew their diagnosis. The most employed treatments were non-steroidal anti-inflammatory drugs (289 patients, 58.5%). The variables associated with treatment were age >58 years (OR 1.3, 95% CI 1.0-1.5), female gender (OR 1.17, 95% CI 1.0-1.3), VAS pain ≥4 (OR 1.3, 95% CI 1.1-1.4), functional disability (OR 2.6, 95% CI 1.6-4.1), HAQ >0.375 (OR 1.9, 95% CI 1.5-2.4), and past diagnosis of OA (OR 5.1, 95% CI 3.3-8.0). In the multivariate analysis, VAS pain ≥4 (OR 1.9, 95% CI 1.2-2.8), kneeling disability (OR 3.15, 95% CI 1.3-7.4) and previous diagnosis of OA (OR 7.6, 95% CI 4.5-12.9) had statistical significance.
CONCLUSION
factors associated with treatment of OA are VAS pain ≥4, kneeling disability and previous diagnosis of OA.
引言
骨关节炎（OA）是墨西哥最常见的风湿性疾病。治疗包括药物和非药物策略。
目的
描述新莱昂州城乡人口中与骨关节炎治疗相关的因素。
方法
对来自COPCORD研究数据库的骨关节炎患者进行横断面研究分析。对与骨关节炎治疗相关的变量进行单因素和多因素分析。
结果
我们纳入了696例骨关节炎患者，平均年龄58岁（标准差14.1），484例（69.5%）为女性。507例（72.8%）患者的视觉模拟量表（VAS）疼痛评分≥4。133例（19%）患者存在功能障碍，平均健康评估问卷（HAQ）评分为0.37（四分位间距0.75）。骨关节炎最常发生在膝关节，有356例（51.1%）患者；259例（37%）患者已经知晓自己的诊断。最常用的治疗方法是非甾体抗炎药（289例患者，58.5%）。与治疗相关的变量包括年龄>58岁（比值比[OR]1.3，95%置信区间[CI]1.0 - 1.5）、女性（OR 1.17，95% CI 1.0 - 1.3）、VAS疼痛评分≥4（OR 1.3，95% CI 1.1 - 1.4）、功能障碍（OR 2.6，95% CI 1.6 - 4.1）、HAQ>0.375（OR 1.9，95% CI 1.5 - 2.4）以及既往骨关节炎诊断（OR 5.1，95% CI 3.3 - 8.0）。在多因素分析中，VAS疼痛评分≥4（OR 1.9，95% CI 1.2 - 2.8）、跪姿功能障碍（OR 3.15，95% CI 1.3 - 7.4）和既往骨关节炎诊断（OR 7.6，95% CI 4.5 - 12.9）具有统计学意义。
结论
与骨关节炎治疗相关的因素是VAS疼痛评分≥4、跪姿功能障碍和既往骨关节炎诊断。
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