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在不适于血管腔内血运重建的严重肢体缺血患者中,静脉与聚四氟乙烯人工血管胫腓旁路移植术的比较。

Comparison of venous and HePTFE tibial and peroneal bypasses in critical limb ischemia patients unsuitable for endovascular revascularization.

作者信息

Uhl Christian, Hock Carolin, Betz Thomas, Greindl Markus, Töpel Ingolf, Steinbauer Markus

机构信息

Department of Vascular Surgery, Krankenhaus Barmherzige Brüder Regensburg, Germany

Department of Vascular Surgery, Krankenhaus Barmherzige Brüder Regensburg, Germany.

出版信息

Vascular. 2015 Dec;23(6):607-13. doi: 10.1177/1708538114568701. Epub 2015 Jan 26.

Abstract

BACKGROUND

We examined short- and long-term outcomes of tibial and peroneal venous and heparin-bonded expanded polytetrafluoroethylene bypasses in patients with critical limb ischemia who were unsuitable for endovascular revascularization.

METHODS

A retrospective analysis was done for all patients who underwent tibial and peroneal bypass surgery in our department between October 2007 and October 2012. Vein was the preferred graft material and used whenever possible.

RESULTS

One hundred and ninety-eight crural grafts were included. Indications for the surgery were rest pain (30.3%) or ulcer or gangrene (69.7%). Autologous veins were used in 109 cases (vein group) and heparin-bonded expanded polytetrafluoroethylene grafts were used in 89 cases (heparin-bonded expanded polytetrafluoroethylene group). At three years, primary patency for the vein group was 68.2% versus 34.1% for the heparin-bonded expanded polytetrafluoroethylene group (P = .000) and secondary patency was 69.8% versus 35.5% (P = .001). Limb salvage was 81.8% for the vein group versus 56.5% for the heparin-bonded expanded polytetrafluoroethylene group (P = .000) and survival was 62.8% versus 46.7% (P = .019).

CONCLUSIONS

The results of our study show that autologous vein grafts are still first choice for tibial and peroneal bypasses in patients with critical limb ischemia. If no adequate vein is available, heparin-bonded expanded polytetrafluoroethylene bypasses are an acceptable alternative to an otherwise impending major amputation.

摘要

背景

我们研究了胫腓静脉及肝素结合型膨体聚四氟乙烯旁路移植术在不适于血管腔内血运重建的严重肢体缺血患者中的短期和长期疗效。

方法

对2007年10月至2012年10月间在我科接受胫腓旁路手术的所有患者进行回顾性分析。静脉是首选的移植材料,只要有可能就使用。

结果

共纳入198条小腿移植血管。手术指征为静息痛(30.3%)或溃疡或坏疽(69.7%)。109例使用自体静脉(静脉组),89例使用肝素结合型膨体聚四氟乙烯移植物(肝素结合型膨体聚四氟乙烯组)。三年时,静脉组的一期通畅率为68.2%,而肝素结合型膨体聚四氟乙烯组为34.1%(P = 0.000),二期通畅率分别为69.8%和35.5%(P = 0.001)。静脉组的肢体挽救率为81.8%,肝素结合型膨体聚四氟乙烯组为56.5%(P = 0.000),生存率分别为62.8%和46.7%(P = 0.019)。

结论

我们的研究结果表明,自体静脉移植物仍是严重肢体缺血患者胫腓旁路移植术的首选。如果没有足够的静脉可用,肝素结合型膨体聚四氟乙烯旁路移植术是避免即将进行的大截肢的可接受替代方案。

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