哈利斯科胺对尖孢镰刀菌黄瓜专化型的活性：体内外分析

Activity of Haliscosamine against Fusarium oxysporum f.sp. melonis: in vitro and in vivo analysis.

作者信息

El Amraoui Belakssem, Biard Jean François, Ikbal Fatima Ez-Zohra, El Wahidi Majida, Kandil Mostafa, El Amraoui Mohammed, Fassouane Aziz

机构信息

Faculté Polydisciplinaire de Taroudant, Université Ibn Zohr, Taroudant, Maroc ; Laboratoire Contrôle Qualité en Bio-Industrie et Molécules Bio-Actives, Faculté des Sciences, Université Chouaib Doukkali, BP 20, El Jadida, 24000 Maroc.

Laboratoire MMS, Faculté de Pharmacie Université de Nantes, Nantes, France.

出版信息

Springerplus. 2015 Jan 13;4:16. doi: 10.1186/s40064-015-0797-x. eCollection 2015.

DOI:10.1186/s40064-015-0797-x

PMID:25625038

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4302159/

Abstract

Marine sponges are a potential source of new molecules with diverse biological activities. We have previously isolated a sphingosine derivative, (9Z)-2-amino-docos-9-ene-1,3,13,14-tetraol (Haliscosamine) from the Moroccan sea sponge Haliclona viscosa. The aim of this study was to test Haliscosamine in vitro and in vivo for its antifungal activity against Fusarium oxysporum f.sp. melonis causing fusarium wilt of melon. Overall, in vitro test showed that haliscosamine has a similar effect as DESOGERME SP VEGETAUX®. In addition, in vivo showed a significant effect against Fusarium oxysporum f.sp. melonis. Taking to gather, our results suggest that haliscosamine constitutes a potential candidate against Fusarium oxysporum f.sp. melonis and the possibility to use in phytopathology.

摘要

海洋海绵是具有多种生物活性的新分子的潜在来源。我们之前从摩洛哥海海绵Haliclona viscosa中分离出一种鞘氨醇衍生物，(9Z)-2-氨基-二十二碳-9-烯-1,3,13,14-四醇（Haliscosamine）。本研究的目的是在体外和体内测试Haliscosamine对引起甜瓜枯萎病的尖孢镰刀菌甜瓜专化型的抗真菌活性。总体而言，体外测试表明Haliscosamine具有与DESOGERME SP VEGETAUX®相似的效果。此外，体内实验显示对尖孢镰刀菌甜瓜专化型有显著效果。综合来看，我们的结果表明Haliscosamine是对抗尖孢镰刀菌甜瓜专化型的潜在候选物，并且有可能用于植物病理学。