Araújo Marcelo Augusto de, Beloti Carolina Aparecida Carlin, Deschk Maurício, Arruda André Moreira Martins, Cheng Lu Shi, Albuquerque Verônica Batista de, Santos Paulo Sergio Patto dos
Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
Faculty of Veterinary Medicine, Sao Paulo State University, Araçatuba, SP, Brazil.
Acta Cir Bras. 2015 Jan;30(1):67-72. doi: 10.1590/S0102-86502015001000009.
To assess the bispectral index (BIS) and recovery in calves anesthetized with xylazine, midazolam, ketamine and isoflurane and subjected to CRI of lidocaine.
Xilazine was administered followed by ketamine and midazolam, orotracheal intubation and maintenance on isoflurane using mechanical ventilation. Lidocaine (2 mg kg(-1) bolus) or saline (0.9%) was administered i.v. followed by a CRI (100 µg kg(-1) minute(-1)) of lidocaine (L) or saline (C). Were recorded BIS, heart rate (HR), mean arterial pressure (MAP) and rectal temperature (RT) before administration of premedication (TB) and 15 minutes after (TX), before administering lidocaine (T0) and 20, 40, 60 and 80 minutes after the start of the CRI . Time do sternal recumbency (SRE) and standing (ST) and plasma lidocaine concentration also evaluated.
In both treatments BIS decreased significantly at all times compared to TB. TX was higher than the subsequent times. HR decreased from baseline at all times and decreased from T40 in L compared to C. SRE was higher in L compared to C.
Bispectral index values were consistent with the degree of hypnosis of the animals. Lidocaine did not potentiate isoflurane anesthesia assessed by BIS in unstimulated calves anesthetized with constant E´Iso. Lidocaine increased the time to sternal recumbency.
评估用赛拉嗪、咪达唑仑、氯胺酮和异氟烷麻醉并接受利多卡因持续输注（CRI）的犊牛的脑电双频指数（BIS）及恢复情况。
先给予赛拉嗪，随后给予氯胺酮和咪达唑仑，行气管插管，使用机械通气维持异氟烷麻醉。静脉注射利多卡因（2mg/kg负荷量）或生理盐水（0.9%），随后给予利多卡因（L组）或生理盐水（C组）持续输注（100μg/kg·分钟-1）。记录麻醉前用药前（TB）、用药后15分钟（TX）、给予利多卡因前（T0）以及持续输注开始后20、40、60和80分钟时的BIS、心率（HR）、平均动脉压（MAP）和直肠温度（RT）。还评估了侧卧（SRE）和站立（ST）时间以及血浆利多卡因浓度。
与TB相比，两种治疗方法在所有时间点BIS均显著降低。TX时高于随后各时间点。HR在所有时间点均较基线下降，与C组相比，L组在T40时HR下降。与C组相比，L组的SRE时间更长。
脑电双频指数值与动物的催眠程度一致。在以恒定异氟烷麻醉且未受刺激的犊牛中，利多卡因并未增强通过BIS评估的异氟烷麻醉效果。利多卡因增加了侧卧时间。
