Zhuang Quan, Lakkis Fadi G
1] Thomas E. Starzl Transplantation Institute and the Departments of Surgery, Immunology, and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA [2] Department of Transplantation, The 3rd Xiangya Hospital, Central South University, Changsha, Hunan, China.
Thomas E. Starzl Transplantation Institute and the Departments of Surgery, Immunology, and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Kidney Int. 2015 Apr;87(4):712-8. doi: 10.1038/ki.2014.430. Epub 2015 Jan 28.
This review summarizes emerging concepts related to the roles of dendritic cells (DCs) and innate immunity in organ transplant rejection. First, it highlights the primary role that recipient, rather than donor, DCs have in rejection and reviews their origin and function in the transplanted kidney. Second, it introduces the novel concept that recognition of allogeneic non-self by host monocytes (referred to here as innate allorecognition) is necessary for initiating rejection by inducing monocyte differentiation into mature, antigen-presenting DCs. Both concepts provide opportunities for preventing rejection by targeting monocytes or DCs.
本综述总结了与树突状细胞（DCs）和固有免疫在器官移植排斥反应中的作用相关的新观点。首先，强调了受体而非供体DCs在排斥反应中的主要作用，并综述了它们在移植肾中的起源和功能。其次，介绍了一个新观点，即宿主单核细胞对同种异体非自身的识别（本文称为固有同种异体识别）通过诱导单核细胞分化为成熟的抗原呈递DCs来启动排斥反应是必要的。这两个观点都为通过靶向单核细胞或DCs来预防排斥反应提供了机会。
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