Gaillard J M, Tissot R
Int Pharmacopsychiatry. 1975;10(4):199-207. doi: 10.1159/000468195.
This study investigates the effect of flunitrazepam, a new benzodiazepine, on the sleep of insomniac patients under chronic treatment. Polygraphic recordings have shown that this drug decreases not only the activity of the wakefulness system, but also the activity of the synchronizing system of slow-wave sleep. The subjective feeling of improved and sounder sleep seems to be related to a decrease of wakefulness pressure as well as to a decrease of body motoricity, but not with the modification of sleep stages themselves. Flunitrazepam appears to possess some regulatory properties on REM sleep, since this stage is enhanced in patients with an initial low amount of REM sleep and decreased in those having a higher initial REM sleep. Flunitrazepam possesses potent and useful hypnogenic properties in man but does not induce physiological sleep.
本研究调查了一种新型苯二氮䓬类药物氟硝西泮对慢性治疗的失眠患者睡眠的影响。多导睡眠图记录显示，这种药物不仅降低了觉醒系统的活动，还降低了慢波睡眠同步系统的活动。睡眠改善和更安稳的主观感觉似乎与觉醒压力的降低以及身体运动性的降低有关，而与睡眠阶段本身的改变无关。氟硝西泮似乎对快速眼动睡眠具有一些调节特性，因为在初始快速眼动睡眠量较低的患者中这个阶段会增强，而在初始快速眼动睡眠量较高的患者中则会降低。氟硝西泮在人体中具有强大且有用的催眠特性，但不会诱导生理性睡眠。
