使用干细胞进行心血管修复和再生的潜力与挑战。

The potential and challenges of using stem cells for cardiovascular repair and regeneration.

作者信息

Sun Qisi, Zhang Zhonge, Sun Zhongjie

机构信息

Yale University, New Haven, CT 06520, USA.

Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

出版信息

Genes Dis. 2014 Sep 1;1(1):113-119. doi: 10.1016/j.gendis.2014.07.003.

DOI:10.1016/j.gendis.2014.07.003

PMID:25642448

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4307803/

Abstract

Recent progress in using stem cells for tissue repair and functional restoration has aroused much attention due to its potential to provide a cue for many diseases such as myocardial infarction. Stem cell therapy for cardiovascular disease has been studied extensively at both experimental and clinical levels. Pluripotent stem cells and mesenchymal stem cells were proven to be effective for myocardial regeneration, angiogenesis, and cardiac functional restoration. In this review, we will concisely discuss advantages and disadvantages of currently-used stem cells for cardiovascular repair and regeneration. The limitations and uniqueness of some types of stem cells will also be discussed. Although substantial progress has been made over the last decade about stem cells in cardiovascular regeneration, many challenges lie ahead before the therapeutic potentials of stem cells can be fully recognized.

摘要

利用干细胞进行组织修复和功能恢复的最新进展因其为诸如心肌梗死等多种疾病提供线索的潜力而备受关注。心血管疾病的干细胞治疗已在实验和临床层面进行了广泛研究。多能干细胞和间充质干细胞已被证明对心肌再生、血管生成和心脏功能恢复有效。在本综述中，我们将简要讨论目前用于心血管修复和再生的干细胞的优缺点。还将讨论某些类型干细胞的局限性和独特性。尽管在过去十年中干细胞在心血管再生方面取得了重大进展，但在干细胞的治疗潜力得到充分认识之前，仍有许多挑战摆在面前。