Mean platelet volume at admission is a determinant of left ventricular thrombus formation after primary percutaneous coronary intervention for first anterior wall myocardial infarction.

OBJECTIVE

Left ventricular thrombus (LVT) is one of the important complications of acute anterior wall myocardial infarction (MI). Mean platelet volume (MPV) is one of the platelet indices reflecting platelet reactivity. In this present study we investigated the effect of MPV on LVT formation after primary percutaneous coronary intervention (PPCI) for first anterior wall MI.

METHODS AND RESULTS

A total of 205 acute anterior wall MI patients were included into this prospective observational study. Patients were divided into two groups according to the presence of LVT. The thrombus (-) group consisted of 161 patients and the thrombus (+) group of 44 patients. Complete blood count (CBC) parameters were measured at admission. Routine biochemical tests and echocardiographic examinations were performed. Groups are compared according to different parameters. With respect to CBC parameters: MPV (9.03 ± 0.76 vs 8.06 ± 0.83) was significantly higher in the thrombus (+) group, platelet count (184.09 ± 52.21 vs 219.88 ± 52.31) was significantly higher in the thrombus (-) group, WBC count (14.01 ± 4.43 vs 11.30 ± 3.53) was also significantly higher in the thrombus (+) group. Furthermore, peak troponin-T level (32.63 ± 20.18 vs 18.70 ± 23.82), CK-MB level at admission (133.49 ± 117.40 vs 71.79 ± 93.96), peak CK-MB level (245.47 ± 89.67 vs 167.37 ± 110.61) were significantly higher in the thrombus (+) group. Logistic regression analysis revealed that MPV was an independent risk factor of LVT formation.

CONCLUSION

In acute anterior wall MI patients MPV is associated with the presence of LVT and is an independent risk factor of LVT formation.