Yu Wubin, Hu Peizhu, Fan Yuanyuan, Yu Congyao, Yan Xinhuan, Li Xiaoqing, Xu Xiangsheng
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, PR China.
Org Biomol Chem. 2015 Mar 21;13(11):3308-13. doi: 10.1039/c4ob01651c.
An efficient metal-free oxidative arylsulfonylation of α,β-unsaturated imides with sulfonylhydrazides leading to isoquinoline-1,3(2H,4H)-dione derivatives has been developed. The procedure involves the generation of sulfonyl radicals via cleavage of the S-N bond of sulfonylhydrazides with sulfonylation and C-H functionalization. The protocol uses the economical and environmentally friendly TBAI-TBHP catalytic system, and the corresponding isoquinoline-1,3(2H,4H)-diones with various functional groups were obtained in moderate to good yields.
已开发出一种高效的无金属氧化芳基磺酰化反应，该反应利用磺酰肼对α,β-不饱和酰亚胺进行反应，生成异喹啉-1,3(2H,4H)-二酮衍生物。该过程涉及通过磺酰肼的S-N键断裂生成磺酰基自由基，并进行磺酰化和C-H官能化反应。该方案使用经济且环境友好的TBAI-TBHP催化体系，以中等至良好的产率获得了具有各种官能团的相应异喹啉-1,3(2H,4H)-二酮。
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