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Autoinhibition and relief mechanism for Polo-like kinase 4.
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E657-66. doi: 10.1073/pnas.1417967112. Epub 2015 Feb 2.
3
Asterless is a Polo-like kinase 4 substrate that both activates and inhibits kinase activity depending on its phosphorylation state.
Mol Biol Cell. 2018 Nov 15;29(23):2874-2886. doi: 10.1091/mbc.E18-07-0445. Epub 2018 Sep 26.
4
The structure of the plk4 cryptic polo box reveals two tandem polo boxes required for centriole duplication.
Structure. 2012 Nov 7;20(11):1905-17. doi: 10.1016/j.str.2012.08.025. Epub 2012 Sep 20.
6
Autophosphorylation of polo-like kinase 4 and its role in centriole duplication.
Mol Biol Cell. 2010 Feb 15;21(4):547-61. doi: 10.1091/mbc.e09-06-0505. Epub 2009 Dec 23.
7
Polo-like kinase 4 autodestructs by generating its Slimb-binding phosphodegron.
Curr Biol. 2013 Nov 18;23(22):2255-2261. doi: 10.1016/j.cub.2013.09.019. Epub 2013 Oct 31.
8
The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification.
J Cell Biol. 2011 Oct 17;195(2):231-43. doi: 10.1083/jcb.201107086. Epub 2011 Oct 10.
10
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
Curr Biol. 2013 Nov 18;23(22):2245-2254. doi: 10.1016/j.cub.2013.09.037. Epub 2013 Oct 31.

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Amplified centrosomes-more than just a threat.
EMBO Rep. 2024 Oct;25(10):4153-4167. doi: 10.1038/s44319-024-00260-0. Epub 2024 Sep 16.
2
Generating CRISPR-edited clonal lines of cultured S2 cells.
Biol Methods Protoc. 2024 Aug 17;9(1):bpae059. doi: 10.1093/biomethods/bpae059. eCollection 2024.
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Spermatocytes have the capacity to segregate chromosomes despite centriole duplication failure.
EMBO Rep. 2024 Aug;25(8):3373-3405. doi: 10.1038/s44319-024-00187-6. Epub 2024 Jun 28.
5
Site-specific phosphorylation of ZYG-1 regulates ZYG-1 stability and centrosome number.
iScience. 2023 Nov 8;26(12):108410. doi: 10.1016/j.isci.2023.108410. eCollection 2023 Dec 15.
6
A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly.
PLoS Biol. 2023 Nov 20;21(11):e3002391. doi: 10.1371/journal.pbio.3002391. eCollection 2023 Nov.
8
Plk4 Is a Novel Substrate of Protein Phosphatase 5.
Int J Mol Sci. 2023 Jan 19;24(3):2033. doi: 10.3390/ijms24032033.
9
Balancing the scales: fine-tuning Polo-like kinase 4 to ensure proper centriole duplication.
Genes Dev. 2022 Jun 1;36(11-12):647-649. doi: 10.1101/gad.349815.122.
10
A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis.
J Biomed Sci. 2022 Apr 1;29(1):24. doi: 10.1186/s12929-022-00807-0.

本文引用的文献

1
The use of cultured Drosophila cells for studying the microtubule cytoskeleton.
Methods Mol Biol. 2014;1136:81-101. doi: 10.1007/978-1-4939-0329-0_6.
2
Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance.
Front Biosci (Landmark Ed). 2014 Jan 1;19(2):352-65. doi: 10.2741/4212.
3
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
Curr Biol. 2013 Nov 18;23(22):2245-2254. doi: 10.1016/j.cub.2013.09.037. Epub 2013 Oct 31.
4
Polo-like kinase 4 autodestructs by generating its Slimb-binding phosphodegron.
Curr Biol. 2013 Nov 18;23(22):2255-2261. doi: 10.1016/j.cub.2013.09.019. Epub 2013 Oct 31.
5
Structural basis for the inhibition of Polo-like kinase 1.
Nat Struct Mol Biol. 2013 Sep;20(9):1047-53. doi: 10.1038/nsmb.2623. Epub 2013 Jul 28.
6
Antimitotic drugs in cancer chemotherapy: promises and pitfalls.
Biochem Pharmacol. 2013 Sep 15;86(6):703-10. doi: 10.1016/j.bcp.2013.07.010. Epub 2013 Jul 22.
7
SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2.
J Cell Biol. 2013 Apr 1;201(1):49-63. doi: 10.1083/jcb.201207183. Epub 2013 Mar 25.
8
Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains.
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):E1222-31. doi: 10.1073/pnas.1301690110. Epub 2013 Mar 11.
9
Advances in characterizing ubiquitylation sites by mass spectrometry.
Curr Opin Chem Biol. 2013 Feb;17(1):49-58. doi: 10.1016/j.cbpa.2012.12.009. Epub 2013 Jan 5.
10
Building a centriole.
Curr Opin Cell Biol. 2013 Feb;25(1):72-7. doi: 10.1016/j.ceb.2012.10.016. Epub 2012 Nov 27.

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