Mekeel Kristin L, Halldorson Jeffery B, Berumen Jennifer A, Hemming Alan W
Division of Transplantation and Hepatobiliary Surgery, University of California San Diego, San Diego, CA, USA.
Clin Transplant. 2015 Apr;29(4):373-8. doi: 10.1111/ctr.12526. Epub 2015 Mar 9.
Although intra-operative vascular complications during renal transplantation are rare, injuries associated with prolonged ischemia may lead to graft threatening early and late complications. This series describes a novel technique for intra-operative repair of vascular complications in five patients over a three-yr period. The method consists of rapid graft nephrectomy and re-preservation of the graft with cold University of Wisconsin solution, which allows for controlled/precise back table repair of the vascular injury without incurring prolonged warm ischemia time. In three cases, the donor renal vein (2) and donor renal artery (1) were damaged and required back table reconstruction. In two cases, the recipient iliac artery needed reconstruction. Three of the five cases used deceased donor iliac vessels from another donor for reconstruction. Two patients required postoperative dialysis for delayed graft function for three to nine d (average six d) and two patients had slow graft function. All grafts were functioning at 17 months (mean) after transplant, with a median serum of 1.61 mg/dL (0.74-3.69). This series demonstrates the effectiveness of kidney clamp, perfuse, resuscitate as an effective intra-operative technique to salvage grafts after vascular injury. Although the grafts may suffer from delayed or slow graft function, excellent long-term function is attainable.
尽管肾移植术中血管并发症很少见,但与长时间缺血相关的损伤可能导致移植肾出现早期和晚期的严重并发症。本系列描述了一种在三年期间对五例患者进行术中血管并发症修复的新技术。该方法包括快速切除移植肾并用冷的威斯康星大学溶液重新保存移植肾,这使得在不延长热缺血时间的情况下,能够在体外对血管损伤进行可控/精确修复。三例中,供体肾静脉(2例)和供体肾动脉(1例)受损,需要在体外进行重建。两例中,受体髂动脉需要重建。五例中有三例使用了来自另一个供体的尸体供体髂血管进行重建。两名患者因移植肾功能延迟需术后透析三至九天(平均六天),两名患者移植肾功能恢复缓慢。所有移植肾在移植后17个月(平均)时均功能良好,血清肌酐中位数为1.61mg/dL(0.74 - 3.69)。本系列证明了肾钳夹、灌注、复苏作为一种有效的术中技术,可在血管损伤后挽救移植肾。尽管移植肾可能出现功能延迟或恢复缓慢,但可实现良好的长期功能。