与严重成人抽动秽语综合征相关的异常皮质联合可塑性。
Aberrant cortical associative plasticity associated with severe adult Tourette syndrome.
作者信息
Martín-Rodríguez Juan Francisco, Ruiz-Rodríguez María Adilia, Palomar Francisco J, Cáceres-Redondo María Teresa, Vargas Laura, Porcacchia Paolo, Gómez-Crespo Mercedes, Huertas-Fernández Ismael, Carrillo Fátima, Madruga-Garrido Marcos, Mir Pablo
机构信息
Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
出版信息
Mov Disord. 2015 Mar;30(3):431-5. doi: 10.1002/mds.26151. Epub 2015 Feb 4.
BACKGROUND
Recent studies have shown altered cortical plasticity in adult patients with Tourette syndrome. However, the clinical significance of this finding remains elusive.
METHODS
Motor cortical plasticity was evaluated in 15 adult patients with severe Tourette syndrome and 16 healthy controls using the paired associative stimulation protocol by transcranial magnetic stimulation. Associations between paired associative stimulation-induced plasticity and relevant clinical variables, including cortical excitability, psychiatric comorbidities, drug treatment and tic severity, were assessed.
RESULTS
Motor cortical plasticity was abnormally increased in patients with Tourette syndrome compared with healthy subjects. This abnormal plasticity was independently associated with tic severity.
CONCLUSION
Patients with severe Tourette syndrome display abnormally increased cortical associative plasticity. This aberrant cortical plasticity was associated with tic severity, suggesting an underlying mechanism for tic pathophysiology.
背景
近期研究表明，患有图雷特综合征的成年患者存在皮质可塑性改变。然而，这一发现的临床意义仍不明确。
方法
采用经颅磁刺激的配对联想刺激方案，对15名患有严重图雷特综合征的成年患者和16名健康对照者的运动皮质可塑性进行评估。评估了配对联想刺激诱导的可塑性与相关临床变量之间的关联，这些变量包括皮质兴奋性、精神共病、药物治疗和抽动严重程度。
结果
与健康受试者相比，图雷特综合征患者的运动皮质可塑性异常增加。这种异常可塑性与抽动严重程度独立相关。
结论
患有严重图雷特综合征的患者表现出异常增加的皮质联想可塑性。这种异常的皮质可塑性与抽动严重程度相关，提示抽动病理生理学的潜在机制。
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