McCarty Mark F
Catalytic Longevity, 7831 Rush Rose Drive, Apt. 316, Carlsbad, CA 92009, United States.
Med Hypotheses. 2015 Apr;84(4):350-5. doi: 10.1016/j.mehy.2015.01.018. Epub 2015 Jan 21.
Molecular hydrogen (H2) can scavenge hydroxyl radical and diminish the toxicity of peroxynitrite; hence, it has interesting potential for antioxidant protection. Recently, a number of studies have explored the utility of inhaled hydrogen gas, or of hydrogen-saturated water, administered parenterally or orally, in rodent models of pathology and in clinical trials, oftentimes with very positive outcomes. The efficacy of orally ingested hydrogen-rich water (HW) has been particularly surprising, given that only transient and rather small increments in plasma hydrogen can be achieved by this method. A recent study in mice has discovered that orally administered HW provokes increased gastric production of the orexic hormone ghrelin, and that this ghrelin mediates the favorable impact of HW on a mouse model of Parkinson's disease. The possibility that most of the benefits observed with HW in experimental studies are mediated by ghrelin merits consideration. Ghrelin is well known to function as an appetite stimulant and secretagogue for growth hormone, but it influences physiological function throughout the body via interaction with the widely express GHS-R1a receptor. Rodent and, to a more limited extent, clinical studies establish that ghrelin has versatile neuroprotective and cognitive enhancing activity, favorably impacts vascular health, exerts anti-inflammatory activity useful in autoimmune disorders, and is markedly hepatoprotective. The stimulatory impact of ghrelin on GH-IGF-I activity, while potentially beneficial in sarcopenia or cachectic disorders, does raise concerns regarding the long-term impact of ghrelin up-regulation on cancer risk. The impact of ingesting HW water on ghrelin production in humans needs to be evaluated; if HW does up-regulate ghrelin in humans, it may have versatile potential for prevention and control of a number of health disorders.
分子氢(H₂)可清除羟自由基并降低过氧亚硝酸盐的毒性;因此,它在抗氧化保护方面具有有趣的潜力。最近,许多研究探讨了吸入氢气或经肠胃外或口服给予的富氢水在病理学啮齿动物模型和临床试验中的效用,其结果往往非常积极。鉴于通过这种方法只能使血浆氢实现短暂且相当小幅度的增加,口服富氢水(HW)的功效尤其令人惊讶。最近一项对小鼠的研究发现,口服HW会促使胃中食欲肽ghrelin的分泌增加,并且这种ghrelin介导了HW对帕金森病小鼠模型的有益影响。在实验研究中观察到的HW的大多数益处可能由ghrelin介导,这一可能性值得考虑。众所周知,ghrelin作为食欲刺激剂和生长激素促分泌素发挥作用,但它通过与广泛表达的GHS-R1a受体相互作用影响全身的生理功能。啮齿动物以及在更有限程度上的临床研究表明,ghrelin具有多种神经保护和认知增强活性,对血管健康有积极影响,在自身免疫性疾病中发挥抗炎活性,并且具有显著的肝脏保护作用。ghrelin对GH-IGF-I活性的刺激作用虽然在肌肉减少症或恶病质疾病中可能有益,但确实引发了对ghrelin上调对癌症风险的长期影响的担忧。需要评估饮用HW水对人体ghrelin产生的影响;如果HW确实能上调人体中的ghrelin,那么它在预防和控制多种健康疾病方面可能具有多种潜力。