Lowry Eugene A, Greninger Daniel A, Porco Travis C, Naseri Ayman, Stamper Robert L, Han Ying
*Department of Ophthalmology ‡Francis I. Proctor Foundation §Department of Epidemiology and Biostatistics, Division of Preventive Medicine and Public Health, University of California San Francisco ∥Department of Ophthalmology, San Francisco Veterans Affairs Medical Center, San Francisco, CA †Department of Ophthalmology, Oregon Health and Science University, Portland, OR.
J Glaucoma. 2016 Mar;25(3):e157-61. doi: 10.1097/IJG.0000000000000207.
To compare intraocular pressure (IOP) reduction and complications of resident-performed argon laser trabeculoplasty (ALT) and selective laser trabeculoplasty (SLT).
This was a retrospective, interventional, comparative case series performed at the San Francisco Veterans Affairs Hospital. The study included 77 patients each undergoing 1 resident-performed ALT procedure from April 2006 through November 2009, and 81 patients each undergoing 1 resident-performed SLT procedure from November 2009 through December 2011. Reduction in IOP at 12 months and a longitudinal analysis across 24 months was determined. Secondary outcomes investigated included additional interventions of either repeat trabeculoplasty or trabeculectomy as well as change in eye drop medications.
There was no evidence of a difference between IOP reductions in patients undergoing ALT compared with SLT at 12 months (P=0.41, linear modeling) or across all follow-up appointments (P=0.62, linear-mixed effects regression). Patients undergoing ALT had a significantly increased number of eye drops (+0.6 vs. -0.1 drops, P<0.001, Wilcoxon rank-sum test) and trend toward increased rates of additional interventions (P=0.06, Weibull regression). There was no difference in immediate postprocedure IOP rise between the 2 groups (P=0.75, Wilcoxon rank-sum test) or any evidence of change in visual acuity.
We found no difference in IOP reduction between patients undergoing resident-performed ALT compared with SLT. However, patients undergoing ALT had a significant increase in eye drop medications and trend toward additional interventions compared with patients undergoing SLT.
比较住院医生实施的氩激光小梁成形术(ALT)和选择性激光小梁成形术(SLT)降低眼压(IOP)的效果及并发症。
这是一项在旧金山退伍军人事务医院进行的回顾性、干预性、对比病例系列研究。该研究纳入了77例患者,他们在2006年4月至2009年11月期间均接受了1次住院医生实施的ALT手术;以及81例患者,他们在2009年11月至2011年12月期间均接受了1次住院医生实施的SLT手术。确定了12个月时眼压的降低情况以及24个月的纵向分析结果。研究的次要结局包括重复小梁成形术或小梁切除术等额外干预措施以及眼药水用药的变化。
在12个月时(P = 0.41,线性模型)或所有随访预约中(P = 0.62,线性混合效应回归),接受ALT的患者与接受SLT的患者在眼压降低方面没有差异的证据。接受ALT的患者眼药水使用量显著增加(+0.6滴对 -0.1滴,P < 0.001,Wilcoxon秩和检验),且额外干预率有增加趋势(P = 0.06,威布尔回归)。两组术后即刻眼压升高无差异(P = 0.75,Wilcoxon秩和检验),也没有视力变化的任何证据。
我们发现住院医生实施的ALT患者与SLT患者在降低眼压方面没有差异。然而,与接受SLT的患者相比,接受ALT的患者眼药水用药量显著增加,且有额外干预的趋势。