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小儿白血病患者与正常对照者斜坡的骨髓磁共振成像

Bone marrow magnetic resonance imaging of the clivus in pediatric leukemia patients and normal controls.

作者信息

Nishii Tatsuya, Kono Atsushi K, Akasaka Yoshinobu, Mori Takeshi, Hayakawa Akira, Iijima Kazumoto, Sugimura Kazuro

机构信息

Department of Radiology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Hyogo, Japan,

出版信息

Jpn J Radiol. 2015 Mar;33(3):146-52. doi: 10.1007/s11604-015-0394-5. Epub 2015 Feb 5.

Abstract

PURPOSE

An MRI-based pre-test to determine the probability of pediatric leukemia prior to bone marrow aspiration would be useful to prevent unnecessary exposure to this invasive test. We aimed to evaluate the clivus-to-pons signal intensity ratio (CPR) and visual scoring (VS) on T1-weighted images (T1WI) and diffusion-weighted images (DWI) to distinguish pediatric leukemia patients from normal controls.

MATERIALS AND METHODS

We retrospectively reviewed 1.5-T brain MR images of 13 consecutive leukemia patients (3 girls, 10 boys; mean age, 8.23 years; range, 1-17 years) and 40 age- and gender-matched normal controls. We evaluated differences between leukemia patients and normal controls using Wilcoxon rank-sum and Mann-Whitney U tests with respect to the following parameters: (1) CPR on T1WI (CPRT1WI); (2) CPR on DWI (CPRDWI); (3) VS on T1WI (VST1WI); and (4) VS on DWI (VSDWI).

RESULTS

The CPRT1WI values for leukemia patients and normal controls were 0.77 ± 0.12 and 1.39 ± 0.47, respectively (P < 0.001). The corresponding CPRDWI values were 1.03 ± 0.38 and 0.50 ± 0.17, respectively (P < 0.001). VST1WI and VSDWI were significantly different between the groups (P < 0.001 for both).

CONCLUSION

MRI-based quantitative and qualitative analyses of clival bone marrow on T1WI and DWI can distinguish pediatric leukemia patients from normal subjects.

摘要

目的

在进行骨髓穿刺前,基于磁共振成像(MRI)的预测试以确定小儿白血病的概率,对于防止不必要地接受这种侵入性检查将是有用的。我们旨在评估在T1加权图像(T1WI)和扩散加权图像(DWI)上的斜坡至脑桥信号强度比(CPR)和视觉评分(VS),以区分小儿白血病患者与正常对照。

材料与方法

我们回顾性分析了13例连续白血病患者(3例女孩,10例男孩;平均年龄8.23岁;范围1 - 17岁)和40例年龄及性别匹配的正常对照的1.5T脑部MR图像。我们使用Wilcoxon秩和检验和Mann - Whitney U检验评估白血病患者与正常对照在以下参数方面的差异:(1)T1WI上的CPR(CPRT1WI);(2)DWI上的CPR(CPRDWI);(3)T1WI上的VS(VST1WI);以及(4)DWI上的VS(VSDWI)。

结果

白血病患者和正常对照的CPRT1WI值分别为0.77±0.12和1.39±0.47(P < 0.001)。相应的CPRDWI值分别为1.03±0.38和0.50±0.17(P < 0.001)。两组之间的VST1WI和VSDWI有显著差异(两者P均< 0.001)。

结论

基于MRI对斜坡骨髓在T1WI和DWI上进行的定量和定性分析能够区分小儿白血病患者与正常受试者。

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