细胞应激驱动胰腺可塑性。
Cellular stress drives pancreatic plasticity.
机构信息
Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02215, USA. Department of Cell Biology, Program in Biological and Biomedical Sciences, Graduate School of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA.
Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02215, USA. Present address: Discovery Research Division, Institute of Molecular and Cell Biology, Proteos, Singapore 138673, Singapore. Present affiliation: School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore. Present affiliation: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.
出版信息
Sci Transl Med. 2015 Feb 4;7(273):273ps2. doi: 10.1126/scitranslmed.3010577.
Controversy has long surrounded research on pancreatic beta cell regeneration. Some groups have used nonphysiological experimental methodologies to build support for the existence of pancreatic progenitor cells within the adult pancreas that constantly replenish the beta cell pool; others argue strongly against this mode of regeneration. Recent research has reinvigorated enthusiasm for the harnessing of pancreatic plasticity for therapeutic application--for example, the transdifferentiation of human pancreatic exocrine cells into insulin-secreting beta-like cells in vitro; the conversion of mouse pancreatic acinar cells to beta-like cells in vivo via cytokine treatment; and the potential redifferentiation of dedifferentiated mouse beta cells in vivo. Here, we highlight key findings in this provocative field and provide a perspective on possible exploitation of human pancreatic plasticity for therapeutic beta cell regeneration.
关于胰腺β细胞再生的研究一直存在争议。一些研究小组采用非生理的实验方法，为成年胰腺中持续补充β细胞池的胰腺祖细胞的存在提供支持；而另一些研究小组则强烈反对这种再生模式。最近的研究重新激发了人们对利用胰腺可塑性进行治疗应用的热情，例如，体外将人胰腺外分泌细胞转分化为胰岛素分泌样β细胞；通过细胞因子处理，体内将小鼠胰腺腺泡细胞转化为β样细胞；以及体内潜在的去分化的小鼠β细胞再分化。在这里，我们重点介绍了该领域的关键发现，并就利用人类胰腺可塑性进行治疗性β细胞再生提供了一些观点。
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