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Maspin作为唾液腺肿瘤中的一种肿瘤抑制因子。

Maspin as a tumour suppressor in salivary gland tumour.

作者信息

Tarakji Bassel, Ashok Nipun, Sheirawan Mohammad Kinan, Altamimi Mohammed Alsakran, Alenzi Faris, Azzeghaiby Saleh Nasser, Baroudi Kusai, Nassani Mohammad Zakaria

机构信息

Faculty, Department of Oral Maxillofacial Sciences, Al-Farabi College of Dentistry and Nursing , Riyadh .

Faculty, Department of Restorative Sciences, Al-Farabi College of Dentistry and Nursing , Riyadh .

出版信息

J Clin Diagn Res. 2014 Dec;8(12):ZE05-7. doi: 10.7860/JCDR/2014/9124.5241. Epub 2014 Dec 5.

Abstract

Maspin is a protein that belongs to serin protease inhibitor (serpin) superfamily. The purpose of this study was to review the literature concerning the expression of maspin in salivary gland tumours. A literature search was done using MEDLINE, accessed via the National Library of Medicine PubMed interface. Statistical analysis was not done because only seven studies were available in literature, the collected data were different and the results could not be compared. Expression of maspin was down regulated in more aggressive salivary gland tumours. Maspin may function as a tumour suppressor in salivary gland tumours.

摘要

乳腺丝抑蛋白是一种属于丝氨酸蛋白酶抑制剂(丝氨酸蛋白酶抑制剂)超家族的蛋白质。本研究的目的是回顾有关乳腺丝抑蛋白在涎腺肿瘤中表达的文献。使用通过美国国立医学图书馆PubMed界面访问的MEDLINE进行文献检索。未进行统计分析,因为文献中仅有七项研究,收集的数据不同且结果无法比较。在侵袭性更强的涎腺肿瘤中,乳腺丝抑蛋白的表达下调。乳腺丝抑蛋白可能在涎腺肿瘤中起肿瘤抑制作用。

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引用本文的文献

1
extracts induce apoptosis and inhibit invasion by targeting the maspin gene in human gastric adenocarcinoma cells.
Oncol Lett. 2018 Jan;15(1):243-249. doi: 10.3892/ol.2017.7341. Epub 2017 Nov 3.

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