3-硝基-2-吡啶亚磺酰基介导的固相二硫键连接用于含二硫键环肽的合成。

3-Nitro-2-pyridinesulfenyl-mediated solid-phase disulfide ligation in the synthesis of disulfide bond-containing cyclic peptides.

作者信息

Taguchi Akihiro, Fukumoto Kentarou, Asahina Yuya, Kajiyama Akihiro, Shimura Shunsuke, Hamada Keisuke, Takayama Kentaro, Yakushiji Fumika, Hojo Hironobu, Hayashi Yoshio

机构信息

Department of Medicinal Chemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.

出版信息

Org Biomol Chem. 2015 Mar 21;13(11):3186-9. doi: 10.1039/c5ob00030k.

DOI:10.1039/c5ob00030k

PMID:25657109

Abstract

A new solid-phase disulfide ligation method is developed to prepare a disulfide peptide from two types of Cys-containing peptide fragments with minimum purification steps. In combination with the subsequent intramolecular amide bond formation, a cyclic nonapeptide, oxytocin, was efficiently synthesized as a fundamental model for more complex cyclic peptides.

摘要

开发了一种新的固相二硫键连接方法，以最少的纯化步骤从两种含半胱氨酸的肽片段制备二硫键肽。结合随后的分子内酰胺键形成，高效合成了环九肽催产素，作为更复杂环肽的基本模型。