生长抑素对间脑细胞中血管活性肠肽诱导的生长抑素释放、环磷酸腺苷积累和45Ca2+摄取的抑制作用。
Somatostatin inhibition of VIP-induced somatostatin release, cyclic AMP accumulation and 45Ca2+ uptake in diencephalic cells.
作者信息
Pares-Herbute N, Diaz J, Astier H, Tapia-Arancibia L
机构信息
U.A. 1197 CNRS, University of Montpellier II, France.
出版信息
Eur J Pharmacol. 1989 Feb 28;161(2-3):241-4. doi: 10.1016/0014-2999(89)90852-2.
The effect of somatostatin (SRIF) on VIP induction of SRIF secretion, cyclic AMP accumulation and 45Ca2+ influx was investigated in cultured diencephalic cells. [D-Trp8]SRIF suppressed VIP-stimulated SRIF release and decreased VIP-stimulated cyclic AMP accumulation in a dose-dependent manner. SRIF-14 blocked basal and VIP-stimulated 45Ca2+ entry into cells. The data suggest that the inhibitory effect of SRIF on VIP-induced SRIF release is partly due to a decrease in Ca2+ entry into cells.
在培养的间脑细胞中研究了生长抑素（SRIF）对VIP诱导的SRIF分泌、环磷酸腺苷（cAMP）积累和45Ca2+内流的影响。[D-色氨酸8]SRIF以剂量依赖的方式抑制VIP刺激的SRIF释放，并降低VIP刺激的cAMP积累。SRIF-14阻断基础状态及VIP刺激下的45Ca2+进入细胞。这些数据表明，SRIF对VIP诱导的SRIF释放的抑制作用部分归因于进入细胞的Ca2+减少。
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