幽门括约肌治疗：肉毒杆菌毒素、支架和幽门肌切开术。
Pyloric sphincter therapy: botulinum toxin, stents, and pyloromyotomy.
作者信息
Clarke John O, Snape William J
机构信息
Division of Gastroenterology & Hepatology, Johns Hopkins University, 1830 East Monument Street, Room 425, Baltimore, MD 21205, USA.
Neurogastroenterology and Motility, California Pacific Medical Center, 2340 Clay Street, Room 210, San Francisco, CA 94115, USA.
出版信息
Gastroenterol Clin North Am. 2015 Mar;44(1):127-36. doi: 10.1016/j.gtc.2014.11.010. Epub 2015 Jan 13.
Gastroparesis is a syndrome characterized by delayed gastric emptying with associated symptoms. Gastric emptying is a complex process and pyloric dysfunction may play a key role in select subsets of patients with gastroparesis. Diagnostic tests to measure pyloric physiology are now available and have the potential to be more widely used in clinical practice. Targeted therapies including botulinum toxin, transpyloric stent placement, surgical pyloroplasty and endoscopic pyloromyotomy have been developed. Data are emerging regarding efficacy and durability, but these therapies may play a prominent role in select patients with gastroparesis and pyloric dysfunction.
胃轻瘫是一种以胃排空延迟及相关症状为特征的综合征。胃排空是一个复杂的过程，幽门功能障碍可能在部分胃轻瘫患者亚组中起关键作用。目前已有测量幽门生理功能的诊断测试方法，并且有可能在临床实践中得到更广泛的应用。已经开发出了包括肉毒杆菌毒素、经幽门支架置入、外科幽门成形术和内镜下幽门肌切开术在内的靶向治疗方法。关于这些治疗方法的疗效和持久性的数据正在不断涌现，但这些疗法可能在部分患有胃轻瘫和幽门功能障碍的患者中发挥重要作用。
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