Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Clin Pharmacol Ther. 2015 Feb;97(2):104-8. doi: 10.1002/cpt.25.
The pharmacological treatment of chronic pain is generally hampered by a limited clinical outcome. Hence, there is a strong need for new therapeutic concepts considering the identification of novel targets and related drugs, but also optimization of established therapeutic regimes through individualization. In this issue, focused on "Pain," we discuss some of the recent new concepts in pain treatment, understanding of pain heterogeneity, and subsequent optimization of analgesic treatment, but also novel insights into interactions of nonopioids.
慢性疼痛的药物治疗通常受到临床疗效有限的阻碍。因此，鉴于需要确定新的靶点和相关药物，以及通过个体化优化既定治疗方案，强烈需要新的治疗理念。在本期聚焦“疼痛”的专题中，我们讨论了疼痛治疗的一些最新新概念、对疼痛异质性的理解以及随后的镇痛治疗优化，还探讨了非阿片类药物相互作用的新见解。
