Fariya Mayur, Jain Ankitkumar, Dhawan Vivek, Shah Sanket, Nagarsenker Mangal S
Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai - 400098, India.
Adv Pharm Bull. 2014 Dec;4(Suppl 2):483-91. doi: 10.5681/apb.2014.072. Epub 2014 Dec 31.
The field of drug discovery is ever growing and excipients play a major role in it. A novel class of amphiphiles has been discussed in the review. The review focuses on natural as well as synthetic bolaamphiphiles, their chemical structures and importantly, their ability to self assemble rendering them of great use to pharmaceutical industry. Recent reports on their ability to be used in fabrication of suitable nanosized carriers for drug as well as genes to target site, has been discussed substantially to understand the potential of bolaamphiphiles in field of drug delivery.
药物研发领域不断发展,辅料在其中发挥着重要作用。综述中讨论了一类新型两亲分子。该综述聚焦于天然和合成的双性离子两亲分子、它们的化学结构,以及重要的是,它们的自组装能力使其在制药行业具有很大用途。近期关于它们用于制造适合药物和基因靶向给药的纳米级载体的能力的报道,已得到充分讨论,以了解双性离子两亲分子在药物递送领域的潜力。