Venkatesan Vijayalakshmi, Madhira Soundarya Lakshmi
Department of Stem Cell Research, National Institute of Nutrition (ICMR), Hyderabad, India.
Indian J Med Res. 2014 Nov;140 Suppl(Suppl 1):S98-105.
In recent times, infertility among both man and woman has become a major concern affecting about 20 per cent of the population worldwide and has been attributed in part to several aetiological factors such as changes in lifestyle, which includes sedentary life, dietary habits, sleep anomalies, environmental pollution, etc. Assisted reproductive technologies (ART) have come to the rescue of many such couples, but presence of metabolic disorders such as obesity, diabetes with insulin resistance (IR) and its secondary complications (micro- and macro-vascular complications), become confounders to the outcome of ART. Cell therapies are arising as a new hope in the management of reproductive disorders and currently, the efficacy of mesenchymal stem cells (MSCs) harvested from the adult sources finds wide application in the management of diseases like stroke, neuropathy, nephropathy, myopathy, wounds in diabetes, etc. Given the capacity of MSCs to preferentially home to damaged tissue and modulate the cellular niche/microenvironment to augment tissue repairs and regeneration, the present review outlines the applications of MSCs in the management of infertility/reproductive disorders.
近年来，男性和女性的不孕症已成为一个主要问题，影响着全球约20%的人口，部分原因是多种病因，如生活方式的改变，包括久坐不动的生活方式、饮食习惯、睡眠异常、环境污染等。辅助生殖技术（ART）已拯救了许多此类夫妇，但肥胖、胰岛素抵抗（IR）型糖尿病及其继发并发症（微血管和大血管并发症）等代谢紊乱的存在，成为ART治疗结果的混杂因素。细胞疗法正成为治疗生殖障碍的新希望，目前，从成人来源获取的间充质干细胞（MSCs）的功效在中风、神经病变、肾病、肌病、糖尿病伤口等疾病的治疗中得到广泛应用。鉴于MSCs优先归巢至受损组织并调节细胞生态位/微环境以增强组织修复和再生的能力，本综述概述了MSCs在不孕症/生殖障碍治疗中的应用。
