Jensen Tomas Ostergaard, Robertson Peter, Whybin Ross, Chambers Ian, Lahra Monica, Rawlinson William, Post Jeffrey John
Department of Infectious Diseases and The Albion Centre, Prince of Wales Hospital, Sydney, Australia Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
Serology and Virology Division, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, Australia.
J Clin Microbiol. 2015 May;53(5):1709-11. doi: 10.1128/JCM.03583-14. Epub 2015 Feb 11.
A rapid diagnosis is considered important in HIV care. In 138,911 testing episodes with the Abbott Architect HIV Ag/Ab Combo assay (3,705 reactive samples), a signal-to-cutoff ratio of >151.17 had a positive predictive value of 100% and a sensitivity of 67.4% for the detection of subsequently confirmed HIV infection. We suggest that results higher than this signal-to-cutoff ratio threshold may be reported to clinicians before the completion of confirmatory testing.
快速诊断在艾滋病护理中被认为很重要。在使用雅培Architect HIV抗原/抗体联合检测法进行的138,911次检测中(3705份反应性样本),信号与临界值之比>151.17时,对于后续确诊的HIV感染检测,其阳性预测值为100%,灵敏度为67.4%。我们建议,高于此信号与临界值比阈值的结果可在确认性检测完成前报告给临床医生。