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MDA5-filament, dynamics and disease.
Curr Opin Virol. 2015 Jun;12:20-5. doi: 10.1016/j.coviro.2015.01.011. Epub 2015 Feb 9.
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Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments.
Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):E3340-9. doi: 10.1073/pnas.1208618109. Epub 2012 Nov 5.
3
Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition.
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The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly.
Mol Cell. 2014 Sep 4;55(5):771-81. doi: 10.1016/j.molcel.2014.07.003. Epub 2014 Aug 7.
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Is the Association of the Rare rs35667974 IFIH1 Gene Polymorphism With Autoimmune Diseases a Case of RNA Epigenetics?
J Mol Evol. 2023 Apr;91(2):204-213. doi: 10.1007/s00239-022-10090-0. Epub 2023 Jan 18.
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Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling.
Science. 2013 Feb 8;339(6120):690-3. doi: 10.1126/science.1230949. Epub 2013 Jan 17.
7
Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses.
J Cell Sci. 2012 Oct 15;125(Pt 20):4761-9. doi: 10.1242/jcs.103887. Epub 2012 Jul 13.
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Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral RNA sensing.
J Biol Chem. 2024 Mar;300(3):105711. doi: 10.1016/j.jbc.2024.105711. Epub 2024 Feb 1.
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MDA5 assembles into a polar helical filament on dsRNA.
Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18437-41. doi: 10.1073/pnas.1212186109. Epub 2012 Oct 22.
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Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5.
Cell. 2013 Jan 17;152(1-2):276-89. doi: 10.1016/j.cell.2012.11.048. Epub 2012 Dec 27.

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2
The role of dsRNA A-to-I editing catalyzed by ADAR family enzymes in the pathogeneses.
RNA Biol. 2024 Jan;21(1):52-69. doi: 10.1080/15476286.2024.2414156. Epub 2024 Oct 24.
4
variants are associated with generalised epilepsy preceded by febrile seizures.
J Med Genet. 2024 Aug 29;61(9):895-903. doi: 10.1136/jmg-2024-109950.
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Inverted Alu repeats: friends or foes in the human transcriptome.
Exp Mol Med. 2024 Jun;56(6):1250-1262. doi: 10.1038/s12276-024-01177-3. Epub 2024 Jun 14.
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Innate immune responses to RNA: sensing and signaling.
Front Immunol. 2024 Jan 25;15:1287940. doi: 10.3389/fimmu.2024.1287940. eCollection 2024.
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Nucleic acid-induced inflammation on hematopoietic stem cells.
Exp Hematol. 2024 Mar;131:104148. doi: 10.1016/j.exphem.2023.104148. Epub 2023 Dec 25.
10
Is the Association of the Rare rs35667974 IFIH1 Gene Polymorphism With Autoimmune Diseases a Case of RNA Epigenetics?
J Mol Evol. 2023 Apr;91(2):204-213. doi: 10.1007/s00239-022-10090-0. Epub 2023 Jan 18.

本文引用的文献

2
The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly.
Mol Cell. 2014 Sep 4;55(5):771-81. doi: 10.1016/j.molcel.2014.07.003. Epub 2014 Aug 7.
3
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.
Nature. 2014 Oct 16;514(7522):372-375. doi: 10.1038/nature13590. Epub 2014 Aug 10.
4
Aicardi-Goutières syndrome is caused by IFIH1 mutations.
Am J Hum Genet. 2014 Jul 3;95(1):121-5. doi: 10.1016/j.ajhg.2014.06.007.
5
In vivo ligands of MDA5 and RIG-I in measles virus-infected cells.
PLoS Pathog. 2014 Apr 17;10(4):e1004081. doi: 10.1371/journal.ppat.1004081. eCollection 2014 Apr.
7
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
Elife. 2014 Feb 18;3:e01535. doi: 10.7554/eLife.01535.
8
Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.
Immunity. 2014 Feb 20;40(2):199-212. doi: 10.1016/j.immuni.2013.12.014. Epub 2014 Feb 13.
9
RIG-I forms signaling-competent filaments in an ATP-dependent, ubiquitin-independent manner.
Mol Cell. 2013 Sep 12;51(5):573-83. doi: 10.1016/j.molcel.2013.07.024. Epub 2013 Aug 29.
10
ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon.
EMBO Rep. 2013 Sep;14(9):780-7. doi: 10.1038/embor.2013.102. Epub 2013 Jul 12.

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