Gerber D E, Oxnard G R, Govindan R
Division of Hematology and Oncology, Harold C. Simmons Cancer Center, UT Southwestern Medical Center, Dallas, Texas, USA.
Clin Pharmacol Ther. 2015 May;97(5):447-50. doi: 10.1002/cpt.91. Epub 2015 Apr 3.
The identification of druggable molecular alterations represents one of the greatest advances in cancer treatment. Such progress is particularly evident for lung cancer, which now has numerous molecularly defined subsets such as epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements. However, understanding of the significance of these genomic alterations is largely limited to incurable, metastatic lung cancer. ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial) is a National Cancer Institute-sponsored initiative to address these questions in earlier-stage disease.
可靶向分子改变的识别是癌症治疗领域最重大的进展之一。这一进展在肺癌中尤为明显,肺癌目前有众多分子定义的亚组,如表皮生长因子受体(EGFR)突变和间变性淋巴瘤激酶(ALK)重排。然而,对这些基因组改变意义的理解在很大程度上仅限于无法治愈的转移性肺癌。ALCHEMIST(辅助性肺癌富集标志物识别与测序试验)是美国国立癌症研究所发起的一项计划,旨在解决早期疾病中的这些问题。