Ericson Jessica E, Laughon Matthew M
Department of Pediatrics, Duke University & Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27715, USA.
Department of Pediatrics, UNC Hospitals, The University of North Carolina at Chapel Hill, 101 Manning Drive, CB# 7596, 4th Floor, Chapel Hill, NC 275599-7596, USA.
Clin Perinatol. 2015 Mar;42(1):155-65, ix. doi: 10.1016/j.clp.2014.10.011. Epub 2014 Nov 21.
Chorioamnionitis (CA) is characterized by inflammation of the fetal membranes. The incidence increases with decreasing gestational age at birth. When suspected on clinical criteria, pathologic assessment of the placenta should be performed. Although the mechanisms are not entirely clear, CA predisposes to premature birth, neonatal sepsis, and intraventricular hemorrhage. Its role in respiratory distress syndrome, bronchopulmonary dysplasia, and neurodevelopmental impairment is mixed. Prevention and treatment are ill-defined; antibiotics for preterm premature rupture of membranes reduce the incidence and increase the length of time to delivery. Antibiotics are recommended for infants exposed to CA while laboratory studies are being performed.
绒毛膜羊膜炎（CA）的特征是胎膜发生炎症。其发病率随出生时孕周的减少而增加。当根据临床标准怀疑患有此病时，应进行胎盘的病理评估。虽然其机制尚不完全清楚，但CA易引发早产、新生儿败血症和脑室内出血。它在呼吸窘迫综合征、支气管肺发育不良和神经发育障碍中的作用存在争议。预防和治疗尚不明确；胎膜早破的早产患者使用抗生素可降低发病率并延长分娩时间。在进行实验室检查时，建议对暴露于CA的婴儿使用抗生素。
