Ghoneum Mamdooh H, Badr El-Din Nariman K, Abdel Fattah Salma M, Pan Deyu, Tolentino Lucilene
1. Department of Otolaryngology, Charles Drew University of Medicine and Science, 1731 E. 120th Street, Los Angeles, CA 90059, USA.
2. Department of Zoology, Faculty of Science, University of Mansoura, Mansoura 35516, Egypt.
Int J Biol Sci. 2015 Jan 28;11(3):295-303. doi: 10.7150/ijbs.10586. eCollection 2015.
In the current study, we examined the protective effect of hydroferrate fluid MRN-100 against the carcinogen methylnitronitrosoguanidine (MNNG)-induced gastric and esophageal cancer in rats. MRN-100 is an iron-based compound composed of bivalent and trivalent ferrates. At 33 weeks post treatment with MNNG, rats were killed and examined for the histopathology of esophagus and stomach; liver, spleen, and total body weight; and antioxidant levels in the blood and stomach tissues. Results showed that 17/20 (85%) gastroesophageal tissues from carcinogen MNNG-treated rats developed dysplasia and cancer, as compared to 8/20 (40%) rats treated with MNNG plus MRN-100. In addition, MRN-100 exerted an antioxidant effect in both the blood and stomach tissues by increasing levels of GSH, antioxidant enzymes SOD, CAT, and GPx, and total antioxidant capacity (TAC) level. This was accompanied by a reduction in the total free-radical and malondialdehyde levels. Furthermore, MRN-100 protected against body and organ weight loss. Thus, MRN-100 exhibited significant cancer chemopreventive activity by protecting tissues against oxidative damage in rats, which may suggest its effectiveness as an adjuvant for the treatment of gastric/esophageal carcinoma.
在本研究中，我们检测了高铁酸盐液体MRN-100对致癌物甲基硝基亚硝基胍（MNNG）诱导的大鼠胃癌和食管癌的保护作用。MRN-100是一种由二价和三价铁酸盐组成的铁基化合物。在MNNG处理33周后，处死大鼠并检查食管和胃的组织病理学；肝脏、脾脏和总体重；以及血液和胃组织中的抗氧化水平。结果显示，与接受MNNG加MRN-100治疗的8/20（40%）大鼠相比，接受致癌物MNNG治疗的大鼠中17/20（85%）的胃食管组织出现发育异常和癌症。此外，MRN-100通过提高谷胱甘肽（GSH）、抗氧化酶超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）的水平以及总抗氧化能力（TAC）水平，在血液和胃组织中发挥抗氧化作用。这伴随着总自由基和丙二醛水平的降低。此外，MRN-100可防止体重和器官重量减轻。因此，MRN-100通过保护大鼠组织免受氧化损伤，表现出显著的癌症化学预防活性，这可能表明其作为胃癌/食管癌治疗辅助药物的有效性。
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