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钆布醇-白蛋白用于前列腺磁共振前哨淋巴结成像:犬模型的初步结果

Magnetic resonance sentinel lymph node imaging of the prostate with gadofosveset trisodium-albumin: preliminary results in a canine model.

作者信息

Turkbey Baris, Hoyt Robert F, Agarwal Harsh K, Bernardo Marcelino, Sankineni Sandeep, Johnson Linda, Grant Kinzya B, Rais-Bahrami Soroush, Kobayashi Hisataka, Wood Bradford J, Pinto Peter A, Griffiths Gary L, Choyke Peter L

机构信息

Molecular Imaging Program, NCI, NIH, 10 Center Dr, MSC 1182 Bldg 10, Room B3B85, Bethesda, MD 20892-1088.

Laboratory of Animal Medicine and Surgery NHLBI, NIH, Bethesda, Maryland; Laboratory Animal Science Program, Leidos Biomedical Research Inc. (formerly SAIC-Frederick, Inc.), Frederick National Laboratory for Cancer Research, Frederick, Maryland.

出版信息

Acad Radiol. 2015 May;22(5):646-52. doi: 10.1016/j.acra.2014.12.021. Epub 2015 Feb 13.

Abstract

RATIONALE AND OBJECTIVES

To determine if intraprostatic injection of gadofosveset trisodium mixed with human serum albumin (HSA) can identify sentinel lymph nodes (LNs) draining the prostate on magnetic resonance imaging (MRI) in a canine model.

MATERIALS AND METHODS

Three male canines weighing between 25.7 and 41.3 kg were anesthetized, placed in a 3-T MRI, and a needle was placed transrectally into one side of the prostate using a commercially available intrarectal needle guide. Gadofosveset trisodium premixed with 10% HSA was then administered at doses ranging from 0.1 to 2.5 mL. T1W MRI was performed immediately after injection, and two readers evaluated images for visualization of LNs draining the prostate.

RESULTS

Intraprostatic injection of 0.2 mL gadofosveset trisodium premixed with HSA identified the draining periprostatic LNs in all cases. Delayed images demonstrated upper echelon nodes in the pelvis and the abdomen. Higher volume injections resulted in excessive periprostatic extravasation, whereas lower volume injections resulted in suboptimal visualization of LNs.

CONCLUSIONS

We demonstrate that gadofosveset trisodium (premixed with 10% HSA) injected intraprostatically at 0.2 mL visualized LNs draining the prostate. This approach can be readily adapted for clinical applications such as sentinel LN imaging in prostate cancer patients before surgery.

摘要

原理与目的

确定在犬类模型中,经前列腺内注射与人类血清白蛋白(HSA)混合的钆塞酸二钠,能否在磁共振成像(MRI)上识别引流前列腺的前哨淋巴结(LN)。

材料与方法

对3只体重在25.7至41.3千克之间的雄性犬进行麻醉,置于3-T MRI设备中,使用市售的直肠内针引导器经直肠将针插入前列腺的一侧。然后以0.1至2.5毫升的剂量注射预先与10% HSA混合的钆塞酸二钠。注射后立即进行T1W MRI检查,由两名阅片者评估图像,以观察引流前列腺的LN。

结果

在所有病例中,经前列腺内注射0.2毫升预先与HSA混合的钆塞酸二钠均可识别引流前列腺周围的LN。延迟图像显示盆腔和腹部的高位淋巴结。注射量较大导致前列腺周围过度渗漏,而注射量较小则导致LN的可视化效果欠佳。

结论

我们证明,经前列腺内注射0.2毫升预先与10% HSA混合的钆塞酸二钠可使引流前列腺的LN显影。这种方法可很容易地应用于临床,如在前列腺癌患者手术前进行前哨LN成像。

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