Berk Thomas A, Tam Diamond Y, Werner Liliana, Mamalis Nick, Ahmed Iqbal Ike K
From the University of Toronto Faculty of Medicine (Berk), the Department of Ophthalmology and Vision Sciences (Tam, Ahmed), University of Toronto Faculty of Medicine, Toronto, Trillium Health Partners (Tam, Ahmed) and GoEyecare (Tam, Ahmed), Mississauga, Canada; the Department of Ophthalmology and Visual Sciences (Werner, Mamalis), John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
From the University of Toronto Faculty of Medicine (Berk), the Department of Ophthalmology and Vision Sciences (Tam, Ahmed), University of Toronto Faculty of Medicine, Toronto, Trillium Health Partners (Tam, Ahmed) and GoEyecare (Tam, Ahmed), Mississauga, Canada; the Department of Ophthalmology and Visual Sciences (Werner, Mamalis), John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
J Cataract Refract Surg. 2015 Mar;41(3):674-80. doi: 10.1016/j.jcrs.2014.12.001. Epub 2015 Feb 14.
We present a case of an explanted gold glaucoma micro shunt (GMS Plus) and the subsequent light and electron microscopic analyses. The shunt was implanted in a patient with medically refractive glaucoma. The intraocular pressure (IOP) was stable at 12 mm Hg 6 months postoperatively but spiked to 26 mm Hg 6 months later; membranous growth was visible on the implant gonioscopically. A second gold micro shunt was placed 2 years after the first. The IOP was 7 mm Hg 1 week postoperatively but increased to 23 mm Hg 3 weeks later; similar membranous growth was visible on this implant. One of the shunts was explanted, and light and scanning electron microscopic analyses revealed encapsulation around the shunt exterior and connective tissue invasion of the microstructure. This represents the first electron microscopic analysis of an explanted gold glaucoma micro shunt and the first unequivocal images of the fibrotic pseudo-capsule traversing its microchannels and fenestrations.
Dr. Ahmed is a consultant to and has received research grants from Solx, Inc. No other author has a financial or proprietary interest in any material or method mentioned.
我们报告了一例取出的青光眼金微分流器（GMS Plus）及其后续的光镜和电镜分析情况。该分流器植入了一名药物治疗无效的青光眼患者体内。术后6个月眼压稳定在12 mmHg，但6个月后飙升至26 mmHg；在植入物上通过前房角镜检查可见膜状生长。在首次植入两年后又植入了第二个金微分流器。术后1周眼压为7 mmHg，但3周后升至23 mmHg；在这个植入物上也可见类似的膜状生长。其中一个分流器被取出，光镜和扫描电镜分析显示分流器外部有包囊形成，并且结缔组织侵入了其微观结构。这是对取出的青光眼金微分流器的首次电镜分析，也是首次明确显示纤维化假包膜穿过其微通道和小孔的图像。
艾哈迈德博士是Solx公司的顾问并获得了该公司的研究资助。其他作者对文中提及的任何材料或方法均无财务或所有权权益。
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