雀麦花叶病毒 3' 非翻译序列调控 RNA 复制、重组和病毒粒子装配。

The brome mosaic virus 3' untranslated sequence regulates RNA replication, recombination, and virion assembly.

机构信息

Department of Plant Pathology, University of California, Riverside, CA 925210-0122, USA.

Department of Molecular & Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA.

出版信息

Virus Res. 2015 Aug 3;206:46-52. doi: 10.1016/j.virusres.2015.02.007. Epub 2015 Feb 14.

DOI:10.1016/j.virusres.2015.02.007

PMID:25687214

Abstract

The 3' untranslated region in each of the three genomic RNAs of Brome mosaic virus (BMV) is highly homologous and contains a sequence that folds into a tRNA-like structure (TLS). Experiments performed over the past four decades revealed that the BMV 3' TLS regulates many important steps in BMV infection. This review summarizes in vitro and in vivo studies of the roles of the BMV 3' TLS functioning as a minus-strand promoter, in RNA recombination, and to nucleate virion assembly.

摘要

Brome mosaic virus (BMV) 三种基因组 RNA 的 3' 非翻译区高度同源，包含一个能折叠成 tRNA 样结构（TLS）的序列。过去四十年的实验表明，BMV 3' TLS 调节 BMV 感染的许多重要步骤。本文综述了 BMV 3' TLS 作为负链启动子、在 RNA 重组和衣壳组装中的作用的体外和体内研究。