Hoffman Lindsey M, Salloum Ralph, Fouladi Maryam
Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, USA,
Curr Neurol Neurosci Rep. 2015 Apr;15(4):10. doi: 10.1007/s11910-015-0532-6.
Brain tumors are the leading cause of cancer-related death in children. For the past several decades, therapeutic strategies have centered on cytotoxic chemotherapy and radiation therapy due, in part, to limited understanding of genetic events that underlie tumor initiation and maintenance. Significant improvement in high-throughput genomic methods, such as next-generation sequencing, methylation array, and copy number array, in recent years has propelled the knowledge base from which novel therapies are derived. Translation of recent genomic findings into more effective therapies remains the most formidable challenge in improving the outcome for children with brain tumors.
脑肿瘤是儿童癌症相关死亡的主要原因。在过去几十年里，治疗策略主要集中在细胞毒性化疗和放射治疗上，部分原因是对肿瘤发生和维持的遗传事件了解有限。近年来，高通量基因组方法，如下一代测序、甲基化阵列和拷贝数阵列，取得了显著进展，推动了新疗法的知识基础。将最近的基因组研究结果转化为更有效的疗法，仍然是改善脑肿瘤患儿治疗效果最艰巨的挑战。
