Gastelum-Aviña Paola, Velazquez Carlos, Espitia Clara, Lares-Villa Fernando, Garibay-Escobar Adriana
Instituto Tecnológico de Sonora, 5 de febrero 818 sur, Cd. Obregón, Sonora, 85000, México.
Expert Rev Vaccines. 2015 May;14(5):699-711. doi: 10.1586/14760584.2015.1015995. Epub 2015 Feb 19.
It is known that cellular immune response is relevant to fight against tuberculosis (TB); hence, identification of mycobacterial antigens that induce a protective immune cellular response is of great interest, especially for the development of effective TB vaccines. Genomic data have an impact on the identification of potential antigens as new vaccine targets. In this review, we summarize the current knowledge about the advances in new TB vaccine designs as well as the features reported for the pro-glu_polymorphic GC-rich sequence (PE_PGRS33) protein, considering this molecule as a prototype of the PE_PGRS family to better understand the biological function of this protein family that could be considered an ideal target for future vaccine design.
众所周知，细胞免疫反应与抗击结核病（TB）相关；因此，鉴定能够诱导保护性免疫细胞反应的分枝杆菌抗原备受关注，特别是对于开发有效的结核病疫苗而言。基因组数据对鉴定作为新疫苗靶点的潜在抗原具有影响。在本综述中，我们总结了关于新型结核病疫苗设计进展的当前知识，以及针对富含GC的前谷氨酸多态性序列（PE_PGRS33）蛋白所报道的特征，将该分子视为PE_PGRS家族的原型，以便更好地理解这个可能被视为未来疫苗设计理想靶点的蛋白家族的生物学功能。
