一项使用24种多态性DNA探针对面肩肱型（兰杜齐-德热里纳型）肌营养不良症进行的基因连锁研究。
A genetic linkage study of facioscapulohumeral (Landouzy-Déjérine) disease with 24 polymorphic DNA probes.
作者信息
Upadhyaya M, Sarfarazi M, Lunt P W, Broadhead W, Harper P S
机构信息
Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff.
出版信息
J Med Genet. 1989 Aug;26(8):490-3. doi: 10.1136/jmg.26.8.490.
Abstract
From analysis of DNA polymorphisms in a panel of 455 subjects from 25 families with facioscapulohumeral (Landouzy-Déjérine) disease, we have found no evidence for close linkage of the disease at 24 different genetic loci, including one from a candidate chromosomal region. Added to previous data, our results provide direction for future collaborative linkage studies.
摘要
通过对来自25个患有面肩肱型（兰杜齐-德热里纳型）肌营养不良症家族的455名受试者的DNA多态性进行分析，我们发现在24个不同的基因位点，包括一个来自候选染色体区域的位点，均没有证据表明该疾病存在紧密连锁。结合先前的数据，我们的研究结果为未来的合作连锁研究提供了方向。
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Linkage studies in facioscapulohumeral muscular dystrophy.
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A workshop on facioscapulohumeral (Landouzy-Déjérine) disease, Manchester, 16 to 17 November 1988.
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