New York University School of Medicine, United States.
VA Boston Healthcare System, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Boston University School of Medicine, United States.
J Affect Disord. 2015 May 1;176:87-94. doi: 10.1016/j.jad.2015.01.043. Epub 2015 Jan 29.
Symptom-level variation in posttraumatic stress disorder (PTSD) has not yet been examined in the early post-deployment phase, but may be meaningful etiologically, prognostically, and clinically.
Using latent class analysis (LCA), we examined PTSD symptom heterogeneity in a cohort of participants from the Marine Resiliency Study (MRS), a longitudinal study of combat Marines deployed to Iraq and Afghanistan (N=892). Typologies of PTSD symptom presentation were examined at one month pre-deployment and again one, five, and eight months post-deployment.
Heterogeneity in PTSD symptom presentation was evident at each assessment point, and the degree of symptom heterogeneity (i.e., the number of classes identified) differed by time point. Symptom patterns stabilized over time from notable symptom fluctuations during the early post-deployment period to high, medium, and low symptom severity by eight months post-deployment. Hypervigilance and exaggerated startle were frequently endorsed by participants in the initial month post-deployment. Flashbacks, amnesia, and foreshortened future were infrequently endorsed. Greater combat exposure, lifespan trauma, and avoidant coping generally predicted worse outcomes.
Data were self-report and may have limited generalizability due to our lack of women and inclusion of only combat Marines. Attrition and re-ranging of data resulted in significant missing data and affected the representativeness of the sample.
Symptom-level variability is highest in the month following deployment and then stabilizes over time. Should post-deployment assessments occur too soon, they may capture common and transient early post-deployment reactions, particularly anxious arousal.
创伤后应激障碍(PTSD)的症状水平变化尚未在部署后早期阶段进行检查,但在病因学、预后和临床方面可能具有重要意义。
我们使用潜在类别分析(LCA),在一项来自海军陆战队复原力研究(MRS)的参与者队列中检查了 PTSD 症状异质性,这是一项对部署到伊拉克和阿富汗的战斗海军陆战队员进行的纵向研究(N=892)。在部署前一个月和部署后一个月、五个月和八个月时,检查了 PTSD 症状表现的类型学。
在每个评估点都明显存在 PTSD 症状表现的异质性,症状异质性的程度(即确定的类别数量)因时间点而异。症状模式在时间上趋于稳定,从早期部署期间明显的症状波动到八个月后部署后的高、中、低症状严重程度。高度警觉和过度惊吓在部署后一个月内经常被参与者认可。闪回、健忘和未来缩短则很少被认可。更高的战斗暴露、寿命期创伤和回避应对通常预示着更差的结果。
数据是自我报告的,由于我们缺乏女性和仅包括战斗海军陆战队员,可能具有有限的普遍性。数据的缺失和重新分类导致了大量缺失数据,并影响了样本的代表性。
在部署后的第一个月,症状水平的变化最大,然后随着时间的推移趋于稳定。如果在部署后进行评估,可能会捕获常见的和短暂的早期部署反应,特别是焦虑唤醒。