生物活性苯并呋喃衍生物：对过去十年的先导化合物开发、放射性配体和进展的深入了解。
Bioactive benzofuran derivatives: An insight on lead developments, radioligands and advances of the last decade.
机构信息
Department of Chemistry, Saurashtra University, University Road, Rajkot 360005, Gujarat, India.
Department of Chemistry, Saurashtra University, University Road, Rajkot 360005, Gujarat, India.
出版信息
Eur J Med Chem. 2015 Jun 5;97:356-76. doi: 10.1016/j.ejmech.2015.01.021. Epub 2015 Jan 13.
Benzofuran core is a highly versatile, presents in many important natural products and natural drugs. Many benzofuran containing synthetic drugs and clinical candidates have been derived from natural products. The present review will provide an insight on lead design-developments of the decade, clinical candidates and PET tracer radio-ligands containing benzofuran core along with brief target biology. Brief of the all approved drugs containing benzofuran core also have been enclosed. Main therapeutic areas covered are Cancer, Neurological disorders including anti-psychotic agent and diabetes.
苯并呋喃核是一种用途广泛的结构，存在于许多重要的天然产物和天然药物中。许多含苯并呋喃的合成药物和临床候选药物都源自天然产物。本综述将深入探讨过去十年中以苯并呋喃核为基础的先导化合物的设计与开发、含有苯并呋喃核的临床候选药物和正电子发射断层扫描（PET）示踪放射性配体，以及简要的靶标生物学。同时还包括了所有含有苯并呋喃核的已批准药物的概述。涵盖的主要治疗领域包括癌症、神经紊乱（包括抗精神病药物）和糖尿病。
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