帕金森病患者在接受和未接受深部脑刺激时言语中关系性时间的保持
Preservation of relational timing in speech of persons with Parkinson's disease with and without deep brain stimulation.
作者信息
Sidtis John J, Van Lancker Sidtis Diana
机构信息
Brain and Behavior Laboratory, Geriatrics Division, The Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962 ; Department of Psychiatry, New York University Langone Medical School, 550 First Avenue, New York, NY 10016.
Brain and Behavior Laboratory, Geriatrics Division, The Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962 ; Department of Communicative Sciences and Disorders, New York University, 665 Broadway, New York, NY 10012.
出版信息
J Med Speech Lang Pathol. 2012 Dec 1;20(4):140-143.
BACKGROUND
Initial shortening of stem vowels in three-word derivational paradigms (e.g., zip, zipper, zippering) was studied in persons with Parkinson's disease (PWPD) with and without deep brain stimulation (DBS), and in normal speakers.
METHOD
Seven PWPD without DBS, 7 PWPD with DBS ON (DBSN) or OFF (DBSF), and 6 healthy control (CON) persons were studied. Stimuli were 7 three-word paradigms consisting of a stem word and two derived longer forms created by adding the suffixes , and .
RESULTS
Vowel durations decreased across word forms of increasing length (initial shortening) for DBSF, DBSN, PWPD, and CON. Vowel shortening did not interact with group. For each word form, CON vowel duration was shorter than those for PWPD, DBSN and DBSF but word duration did not differ between groups. DBS did not have a significant effect on either vowel or word duration.
CONCLUSION
These results agree with previous findings for a PWPD with accelerated speech and faster rates of speech in DBS-ON. Observations that vowel duration patterns are maintained in subcortical and cerebellar but not left hemisphere damage suggest that cortical control factors play a primary role in relational timing.
背景
研究了帕金森病患者（PWPD）在有或没有深部脑刺激（DBS）的情况下，以及正常说话者在三字派生范式（如zip、zipper、zippering）中词干元音的初始缩短情况。
方法
研究了7名未接受DBS的PWPD患者、7名DBS开启（DBSN）或关闭（DBSF）的PWPD患者以及6名健康对照（CON）者。刺激材料为7个三字范式，由一个词干词和通过添加后缀 和 创造的两个派生的较长形式组成。
结果
对于DBSF、DBSN、PWPD和CON组，元音时长随着词形长度增加而缩短（初始缩短）。元音缩短与组别无交互作用。对于每种词形，CON组的元音时长比PWPD组、DBSN组和DBSF组短，但词时长在各组之间无差异。DBS对元音时长或词时长均无显著影响。
结论
这些结果与之前关于PWPD患者在DBS开启时语速加快的研究结果一致。在皮层下和小脑损伤但非左半球损伤中元音时长模式得以维持的观察结果表明，皮层控制因素在关系计时中起主要作用。
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